SPI1 (PU.1), CEBPA and DEK bind the promoter of the CSF3R (G-CSFR) gene

Stable Identifier
R-HSA-9617207
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The promoter of the CSF3R gene contains 2 binding sites for SPI1 (PU.1) in the 5' untranslated region (Smith et al. 1996). The 3' site binds SPI1 less strongly (Smith et al. 1996). SPI1 and CEBPA appear to act synergistically in activating transcription of CSFR3. Chromatin immunoprecipitation indicates CEBPA and DEK1 together bind the CSF3R promoter and depletion of DEK1 reduces activation of transcription by CEBPA (Koleva et al. 2012).

Literature References
PubMed ID Title Journal Year
22474248 C/EBPα and DEK coordinately regulate myeloid differentiation

Koleva, RI, Ficarro, SB, Radomska, HS, Carrasco-Alfonso, MJ, Alberta, JA, Webber, JT, Luckey, CJ, Marcucci, G, Tenen, DG, Marto, JA

Blood 2012
8695841 PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells

Smith, LT, Hohaus, S, Gonzalez, DA, Dziennis, SE, Tenen, DG

Blood 1996
Participants
Participant Of
Authored
Reviewed
Created