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Activated calmodulin binds ADCY1,ADCY8
Stable Identifier
R-HSA-9617535
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Post NMDA receptor activation events (Homo sapiens)
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
Activated calmodulin binds ADCY1,ADCY8 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Calmodulin (CALM1, also known as CaM), activated by binding to Ca2+ ions, forms a complex with adenylate cyclase 1 (ADCY1, also known as AC1) (Levin and Reed 1995, Masada et al. 2012) or adenylate cyclase 8 (ADCY8, also known as AC8) (Gu and Cooper 1999, Masada et al. 2012, Herbst et al. 2013), thereby activating them.
Participants
Input
ADCY1,ADCY8 [plasma membrane]
(Homo sapiens)
CALM1:4xCa2+ [cytosol]
(Homo sapiens)
Output
ADCY1,ADCY8:CALM1:4xCa2+ [plasma membrane]
(Homo sapiens)
Participates
as an event of
CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
Inferred From
Activated calmodulin binds Adcy8 (Rattus norvegicus)
Activated calmodulin binds ADCY1 (Bos taurus)
Authored
Orlic-Milacic, M (2018-10-10)
Reviewed
Hansen, KB (2018-11-02)
Yi, F (2018-11-02)
Created
Orlic-Milacic, M (2018-08-28)
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