Reactome | 2xHC-TXN [nucleoplasm]

2xHC-TXN [nucleoplasm]

Stable Identifier

R-HSA-9617733

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Thioredoxin, oxidized, Thioredoxin, ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10599 TXN

Gene Names

TXN, TRDX, TRX, TRX1

Chain

initiator methionine:1, chain:2-105

Reference Genes

BioGPS Gene:7295 TXN

COSMIC (genes):TXN TXN

CTD Gene:7295 TXN

dbSNP Gene:7295 TXN

ENSEMBL:ENSG00000136810 TXN

HGNC:12435 TXN

KEGG Gene (Homo sapiens):7295 TXN

Monarch:7295 TXN

NCBI Gene:7295 TXN

OMIM:187700 TXN

UCSC:P10599 TXN

Reference Transcript

Other Identifiers

0001980193

0001990195

11715469_s_at

11715470_x_at

11750538_x_at

11753775_x_at

11753804_x_at

17097052

1AIU

1AUC

1CQG

1CQH

1ERT

1ERU

1ERV

1ERW

1M7T

1MDI

1MDJ

1MDK

1TRS

1TRU

1TRV

1TRW

1W1C

1W1E

208864_s_at

2HSH

2HXK

2IFQ

2IIY

3220157

3220158

3220159

3220160

3220162

3220166

3220168

3220174

3220175

36992_at

3E3E

3KD0

3M9J

3M9K

3QFA

3QFB

3TRX

47478

4LL1

4LL4

4OO4

4OO5

4POK

4POL

4POM

4PUF

4TRX

55752

5DQY

7295

8163185

8678

A_23_P60248

AAA74596

AAC17430

AAF86466

AAF87085

AAG34699

AAH03377

AAH54866

AAN33187

AEE61109

AF065241

AF276919

AF313911

AF548001

AFH41799

AK289508

AL158158

AY004872

BAF82197

BC003377

BC054866

CAA38410

CAA54687

CAB008678

CAG28593

CCDS35103

CCDS59139

CH471105

CR407665

EAW59059

EAW59060

ENSG00000136810

ENSP00000363639

ENSP00000363641

ENST00000374515

ENST00000374515.9

ENST00000374517

ENST00000374517.5

EntrezGene:7295

EntrezGene:TXN

g11345419_3p_at

g11345419_3p_s_at

GE81265

GO:0000122

GO:0003674

GO:0003723

GO:0004791

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006662

GO:0006810

GO:0006913

GO:0006950

GO:0007165

GO:0008150

GO:0008219

GO:0009058

GO:0009314

GO:0015031

GO:0015035

GO:0015037

GO:0016491

GO:0032148

GO:0033138

GO:0034641

GO:0042592

GO:0043226

GO:0043388

GO:0044281

GO:0045454

GO:0046826

GO:0051897

GO:0055114

GO:0070062

GO:0098869

GO:1903206

H9ZYJ2

HGNC:12435

HM005512

HPA047478

HPA055752

ILMN_1343293

ILMN_1680314

ILMN_2038776

IPR005746

IPR013766

IPR017937

IPR036249

J04026

JQ313905

MIM:187700

NM_001244938

NM_003329

NP_001231867

NP_003320

PF00085

PH_hs_0030018

PH_hs_0040358

PR00421

TC09001473.hg

TXN

TXN-201

TXN-202

UPI000011065C

UPI00002115DA

X54539

X54540

X54541

X77584

X77584_at

Participant Of

output

Other forms of this molecule

TXN [nucleoplasm]

2xHC-TXN [cytosol]

TXN [cytosol]

Modified Residues

Name

half cystine at 32

Coordinate

PsiMod Name

half cystine [MOD:00798]

PsiMod Definition

A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.

Name

half cystine at 35

Coordinate

PsiMod Name

half cystine [MOD:00798]

PsiMod Definition

A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.

Cross References

RefSeq

NP_003320.2, NP_001231867.1

ZINC - Investigational

THIO_HUMAN

OpenTargets

ENSG00000136810

GeneCards

P10599

ZINC - Substances

THIO_HUMAN

ZINC target

P10599

ZINC - Biogenic

THIO_HUMAN

PRO

P10599

ZINC - Predictions - Purchasable

THIO_HUMAN

PDB

1CQH, 1AIU, 5DQY, 4POK, 1TRU, 1TRS, 1ERU, 1CQG, 1ERV, 2IIY, 3M9K, 3QFA, 1TRW, 1W1E, 4POM, 2IFQ, 1ERW, 4TRX, 1M7T, 1W1C, 1TRV, 2HSH, 4PUF, 4POL, 3E3E, 4OO5, 3KD0, 4OO4, 3QFB, 1AUC, 1MDI, 1MDJ, 4LL4, 3M9J, 1ERT, 4LL1, 3TRX, 1MDK, 2HXK

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.721	4
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.712	5
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.677	4
UniProt:P42574 CASP3	5	CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646) CASP3(1-277) [cytosol] (R-HSA-57021)	0.672	6
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.655	8
UniProt:D0ZRB2 SLRP			0.633	7
UniProt:Q99836 MYD88	9	MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-193946) MYD88 [cytosol] (R-HSA-166059) MYD88 [endosome membrane] (R-HSA-975123) MyD88 E65del [cytosol] (R-HSA-5602598) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 R196C [cytosol] (R-HSA-5602329)	0.602	4
UniProt:P32119 PRDX2	2	PRDX2 [cytosol] (R-HSA-3341292) p-T89-PRDX2 [cytosol] (R-HSA-8868574)	0.564	2
UniProt:P12814 ACTN1	3	ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [cytosol] (R-HSA-354096) ACTN1 [extracellular region] (R-HSA-349722)	0.488	2
UniProt:Q9BXU3 TX13A			0.488	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.488	2
UniProt:Q96D03 DDT4L			0.488	2
UniProt:Q9Y605 MOFA1			0.488	2
UniProt:Q9NZD8 SPG21			0.488	4
UniProt:P19883 FST	1	FST [extracellular region] (R-HSA-2473211)	0.488	2
UniProt:Q9GZT8 NIF3L			0.488	2
UniProt:X5D778 X5D778			0.488	4
UniProt:Q49A26-4 GLYR1			0.488	2
UniProt:Q9UJW9 SRTD3			0.488	2
UniProt:P37198 NUP62	1	NUP62 [nuclear envelope] (R-HSA-157713)	0.488	2
UniProt:O95831 AIFM1			0.462	2