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2xHC-TXN [nucleoplasm]
Stable Identifier
R-HSA-9617733
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Thioredoxin, oxidized, Thioredoxin, ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
2xHC-TXN [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10599 TXN
Gene Names
TXN, TRDX, TRX, TRX1
Chain
initiator methionine:1, chain:2-105
Reference Genes
BioGPS Gene:7295 TXN
COSMIC (genes):TXN TXN
CTD Gene:7295 TXN
dbSNP Gene:7295 TXN
ENSEMBL:ENSG00000136810 TXN
HGNC:12435 TXN
KEGG Gene (Homo sapiens):7295 TXN
Monarch:7295 TXN
NCBI Gene:7295 TXN
OMIM:187700 TXN
UCSC:P10599 TXN
Reference Transcript
RefSeq:NM_003329.3 TXN
RefSeq:NM_001244938.1 TXN
Other Identifiers
0001980193
0001990195
11715469_s_at
11715470_x_at
11750538_x_at
11753775_x_at
11753804_x_at
17097052
1AIU
1AUC
1CQG
1CQH
1ERT
1ERU
1ERV
1ERW
1M7T
1MDI
1MDJ
1MDK
1TRS
1TRU
1TRV
1TRW
1W1C
1W1E
208864_s_at
2HSH
2HXK
2IFQ
2IIY
3220157
3220158
3220159
3220160
3220162
3220166
3220168
3220174
3220175
36992_at
3E3E
3KD0
3M9J
3M9K
3QFA
3QFB
3TRX
47478
4LL1
4LL4
4OO4
4OO5
4POK
4POL
4POM
4PUF
4TRX
55752
5DQY
7295
8163185
8678
A_23_P60248
AAA74596
AAC17430
AAF86466
AAF87085
AAG34699
AAH03377
AAH54866
AAN33187
AEE61109
AF065241
AF276919
AF313911
AF548001
AFH41799
AK289508
AL158158
AY004872
BAF82197
BC003377
BC054866
CAA38410
CAA54687
CAB008678
CAG28593
CCDS35103
CCDS59139
CH471105
CR407665
EAW59059
EAW59060
ENSG00000136810
ENSP00000363639
ENSP00000363641
ENST00000374515
ENST00000374515.9
ENST00000374517
ENST00000374517.5
EntrezGene:7295
EntrezGene:TXN
g11345419_3p_at
g11345419_3p_s_at
GE81265
GO:0000122
GO:0003674
GO:0003723
GO:0004791
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006662
GO:0006810
GO:0006913
GO:0006950
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0009314
GO:0015035
GO:0015037
GO:0016491
GO:0032148
GO:0033138
GO:0034641
GO:0042592
GO:0043226
GO:0043388
GO:0044281
GO:0045454
GO:0046826
GO:0051897
GO:0055114
GO:0070062
GO:0098869
GO:1903206
H9ZYJ2
HGNC:12435
HM005512
HPA047478
HPA055752
ILMN_1343293
ILMN_1680314
ILMN_2038776
IPR005746
IPR013766
IPR017937
IPR036249
J04026
JQ313905
MIM:187700
NM_001244938
NM_003329
NP_001231867
NP_003320
PF00085
PH_hs_0030018
PH_hs_0040358
PR00421
TC09001473.hg
TXN
TXN-201
TXN-202
UPI000011065C
UPI00002115DA
X54539
X54540
X54541
X77584
X77584_at
Participant Of
output
TXN disrupts Foxo4 comples with EP300
TXN disrupts FOXO4 complex with EP300
Other forms of this molecule
TXN [nucleoplasm]
2xHC-TXN [cytosol]
TXN [cytosol]
Modified Residues
Name
half cystine at 32
Coordinate
32
PsiMod Name
half cystine [MOD:00798]
PsiMod Definition
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.
Name
half cystine at 35
Coordinate
35
PsiMod Name
half cystine [MOD:00798]
PsiMod Definition
A protein modification that can be regarded as effectively either one half of a cystine cross-link, or a cysteine residue with one hydrogen atom or proton removed.
Cross References
ZINC - Investigational
THIO_HUMAN
RefSeq
NP_003320.2
,
NP_001231867.1
OpenTargets
ENSG00000136810
GeneCards
P10599
ZINC - Substances
THIO_HUMAN
ZINC - Biogenic
THIO_HUMAN
ZINC target
P10599
PRO
P10599
ZINC - Predictions - Purchasable
THIO_HUMAN
PDB
4PUF
,
1TRW
,
1M7T
,
1W1E
,
1ERW
,
4POL
,
1AUC
,
5DQY
,
4POK
,
2IFQ
,
3QFA
,
1MDJ
,
4POM
,
1ERT
,
1CQG
,
3QFB
,
4TRX
,
1MDI
,
3E3E
,
1MDK
,
3M9J
,
1TRS
,
2HXK
,
1AIU
,
3TRX
,
1CQH
,
4OO4
,
3KD0
,
4OO5
,
1TRU
,
3M9K
,
1ERV
,
1W1C
,
1TRV
,
1ERU
,
2HSH
,
4LL1
,
4LL4
,
2IIY
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.721
4
UniProt:Q9H3M7 TXNIP
2
TXNIP [cytosol]
(R-HSA-1250246)
TXNIP [nucleoplasm]
(R-HSA-9617747)
0.712
5
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.677
4
UniProt:P42574 CASP3
5
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.672
6
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.655
8
UniProt:D0ZRB2 SLRP
0.633
7
UniProt:Q99836 MYD88
9
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-193946)
MYD88 [cytosol]
(R-HSA-166059)
MYD88 [endosome membrane]
(R-HSA-975123)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 R196C [cytosol]
(R-HSA-5602329)
0.602
4
UniProt:P32119 PRDX2
2
PRDX2 [cytosol]
(R-HSA-3341292)
p-T89-PRDX2 [cytosol]
(R-HSA-8868574)
0.564
2
UniProt:Q9BXU3 TX13A
0.488
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
0.488
2
UniProt:Q96D03 DDT4L
0.488
2
UniProt:Q9Y605 MOFA1
0.488
2
UniProt:Q9NZD8 SPG21
0.488
4
UniProt:P19883 FST
1
FST [extracellular region]
(R-HSA-2473211)
0.488
2
UniProt:Q9GZT8 NIF3L
0.488
2
UniProt:X5D778 X5D778
0.488
4
UniProt:Q49A26-4 GLYR1
0.488
2
UniProt:Q9UJW9 SRTD3
0.488
2
UniProt:P37198 NUP62
1
NUP62 [nuclear envelope]
(R-HSA-157713)
0.488
2
UniProt:P12814 ACTN1
3
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [extracellular region]
(R-HSA-349722)
0.488
2
UniProt:O95831 AIFM1
0.462
2
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