Reactome | 2xHC-TXN [nucleoplasm]

2xHC-TXN [nucleoplasm]

Stable Identifier

R-HSA-9617733

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Thioredoxin, oxidized, Thioredoxin, ATL-derived factor, ADF, Surface associated sulphydryl protein, SASP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P10599 TXN

Gene Names

TXN, TRDX, TRX, TRX1

Chain

initiator methionine:1, chain:2-105

Reference Genes

BioGPS Gene:7295 TXN

COSMIC (genes):TXN TXN

CTD Gene:7295 TXN

dbSNP Gene:7295 TXN

ENSEMBL:ENSG00000136810 TXN

ENSEMBL:ENSG00000136810.13 TXN

HGNC:12435 TXN

KEGG Gene (Homo sapiens):7295 TXN

Monarch:7295 TXN

NCBI Gene:7295 TXN

OMIM:187700 TXN

UCSC:P10599 TXN

Reference Transcript

Other Identifiers

11715469_s_at

11715470_x_at

11750538_x_at

11753775_x_at

11753804_x_at

17097052

208864_PM_s_at

208864_s_at

3220157

3220158

3220159

3220160

3220162

3220166

3220168

3220174

3220175

36992_at

7295

8163185

A_23_P60248

GE81265

GO:0000122

GO:0003723

GO:0003824

GO:0004791

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006886

GO:0006913

GO:0009314

GO:0015035

GO:0016209

GO:0016491

GO:0023052

GO:0032148

GO:0033138

GO:0036211

GO:0042803

GO:0043226

GO:0043388

GO:0045454

GO:0046826

GO:0047134

GO:0051897

GO:0061692

GO:0070062

GO:0071731

GO:0098754

GO:0098869

GO:0140096

GO:2000170

HMNXSV003001941

HMNXSV003052323

ILMN_1680314

ILMN_2038776

PH_hs_0030018

PH_hs_0040358

TC09001473.hg

X77584_at

g11345419_3p_at

g11345419_3p_s_at

Participates

as an output of

Other forms of this molecule

TXN [nucleoplasm]

2xHC-TXN [cytosol]

TXN [cytosol]

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 32 and 35

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_003320.2, NP_001231867.1

OpenTargets

ENSG00000136810

ZINC - Substances

THIO_HUMAN

ZINC - Biogenic

THIO_HUMAN

ZINC target

P10599

PRO

P10599

PDB

3E3E, 4LL1, 2IFQ, 1AUC, 1CQG, 1TRV, 1ERV, 1TRU, 4OO5, 1ERU, 1ERT, 3QFB, 4OO4, 1TRS, 2HSH, 1MDK, 3QFA, 4TRX, 4POL, 4POM, 1MDJ, 4PUF, 1MDI, 2IIY, 3M9K, 4LL4, 1AIU, 3M9J, 5DQY, 1TRW, 4POK, 3TRX, 2HXK, 3KD0, 1M7T, 1CQH, 1ERW

ZINC - Investigational

THIO_HUMAN

HPA

ENSG00000136810-TXN

GeneCards

P10599

Ensembl

ENSP00000363641, ENST00000374517, ENSG00000136810, ENSP00000363639, ENST00000374515

Pharos - Targets

P10599

ZINC - Predictions - Purchasable

THIO_HUMAN

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.785	5
UniProt:Q9H3M7 TXNIP	2	TXNIP [nucleoplasm] (R-HSA-9617747) TXNIP [cytosol] (R-HSA-1250246)	0.743	8
UniProt:Q92905 COPS5	2	COPS5 [nucleoplasm] (R-HSA-5697019) COPS5 [cytosol] (R-HSA-416963)	0.736	9
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.677	4
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.675	4
UniProt:P42574 CASP3	5	CASP3(29-175) [nucleoplasm] (R-HSA-211194) CASP3(176-277) [nucleoplasm] (R-HSA-211203) CASP3(1-277) [cytosol] (R-HSA-57021) CASP3(29-175) [cytosol] (R-HSA-141644) CASP3(176-277) [cytosol] (R-HSA-141646)	0.672	6
UniProt:D0ZRB2 SLRP			0.633	7
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.602	4
UniProt:P32119 PRDX2	2	p-T89-PRDX2 [cytosol] (R-HSA-8868574) PRDX2 [cytosol] (R-HSA-3341292)	0.564	2
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q14114-3 Q141143			0.556	3
UniProt:Q9BXU3 TX13A			0.556	3
UniProt:Q96D03 DDT4L			0.556	5
UniProt:Q9Y605 MOFA1			0.556	3
UniProt:Q9NZD8 SPG21			0.556	6
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P37198 NUP62	2	NUP62 [cytosol] (R-HSA-9634226) NUP62 [nuclear envelope] (R-HSA-157713)	0.556	3
UniProt:P23560-2 BDNF			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:X5D778 X5D778			0.556	6
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:P19883 FST	1	FST [extracellular region] (R-HSA-2473211)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.556	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.556	3
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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