Reactome | TXNIP [nucleoplasm]

TXNIP [nucleoplasm]

Stable Identifier

R-HSA-9617747

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Thioredoxin-interacting protein, TXNIP_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O15534 PER1

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - FOXO-mediated transcription (Homo sapiens)
      - Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
        
        TXN disrupts FOXO4 complex with EP300 (Homo sapiens)
        
        TXNIP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H3M7 TXNIP

Gene Names

TXNIP, VDUP1

Chain

chain:1-391

Reference Genes

BioGPS Gene:10628 TXNIP

COSMIC (genes):TXNIP TXNIP

CTD Gene:10628 TXNIP

dbSNP Gene:10628 TXNIP

ENSEMBL:ENSG00000265972 TXNIP

ENSEMBL_homo_sapiens_GENE:ENSG00000265972.6 TXNIP

HGNC:16952 TXNIP

KEGG Gene (Homo sapiens):10628 TXNIP

Monarch:10628 TXNIP

NCBI Gene:10628 TXNIP

OMIM:606599 TXNIP

UCSC:Q9H3M7 TXNIP

Reference Transcript

Other Identifiers

10628

11717190_s_at

11748543_a_at

11748544_s_at

11752765_s_at

11756431_s_at

16669796

201008_PM_s_at

201008_s_at

201009_PM_s_at

201009_s_at

201010_PM_s_at

201010_s_at

2356116

2356117

2356118

2356120

2356121

2356123

2356125

2356127

2356128

2356130

2356132

2356134

2356135

2356136

2356137

2356138

31508_at

64281_s_at

7904726

A_23_P97700

GE58805

GO:0000122

GO:0004857

GO:0005515

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006606

GO:0006886

GO:0006913

GO:0006954

GO:0006979

GO:0007049

GO:0009410

GO:0009612

GO:0009749

GO:0012501

GO:0015031

GO:0023052

GO:0030154

GO:0030216

GO:0031625

GO:0032355

GO:0032570

GO:0042127

GO:0042542

GO:0043065

GO:0048008

GO:0048856

GO:0051592

GO:0051782

GO:0071228

GO:0098772

GO:0140052

HMNXSV003003998

Hs.179526.0.S1_3p_a_at

Hs.179526.0.S2_3p_a_at

ILMN_1697448

PH_hs_0010634

S73591_at

TC01001090.hg

g5454161_3p_a_at

This entity regulates

Negatively

Other forms of this molecule

TXNIP [cytosol]

Cross References

RefSeq

NP_001300901.1, NP_006463.3

OpenTargets

ENSG00000265972

GeneCards

Q9H3M7

HPA

ENSG00000265972-TXNIP

Ensembl

ENSP00000462521, ENSG00000265972, ENST00000582401, ENSP00000396322, ENST00000425134

PRO

Q9H3M7

Pharos - Targets

Q9H3M7

PDB

4ROJ, 4GEI, 4ROF, 5DF6, 4LL1, 5DWS, 5DZD, 5CQ2, 4GEJ, 4LL4, 4GFX

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10599 TXN	4	2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [cytosol] (R-HSA-66000)	0.743	8
UniProt:O95905 ECD			0.688	6
UniProt:P52735 VAV2	2	VAV2 [cytosol] (R-HSA-195012) p-Y172-VAV2 [cytosol] (R-HSA-442307)	0.558	2
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.527	2
UniProt:Q658Y4 FAM91A1	1	FAM91A1 [cytosol] (R-HSA-9714670)	0.527	2
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.527	2
UniProt:Q8WVZ9 KBTBD7	1	KBTBD7 [cytosol] (R-HSA-5658415)	0.527	2
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.527	2
UniProt:Q9NS91 RAD18	1	RAD18 [nucleoplasm] (R-HSA-5643731)	0.527	2
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	2
UniProt:Q9NXF7 DCAF16	1	DCAF16 [nucleoplasm] (R-HSA-8955193)	0.527	2
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.527	2
UniProt:Q86V97 KBTBD6	1	KBTBD6 [cytosol] (R-HSA-8863221)	0.527	2
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.499	3