FOXO3 binds SOD2 gene promoter

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R-HSA-9617972
Type
Reaction [binding]
Species
Homo sapiens
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FOXO3 binds forkhead box elements in the promoter region of the SOD2 gene, encoding mitochondrial manganese-dependent superoxide dismutase (Kops et al. 2002). FOXO3-mediated upregulation of the SOD2 gene transcription is positively regulated by SIRT3 histone deacetylase, which deacetylates FOXO3 under conditions of oxidative stress and increases nuclear localization of FOXO3 (Sundaresan et al. 2009, Rangarajan et al. 2015, Yang et al. 2016).

Literature References
PubMed ID Title Journal Year
12239572 Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

Kops, GJ, Dansen, TB, Polderman, PE, Saarloos, I, Wirtz, KW, Coffer, PJ, Huang, TT, Bos, JL, Medema, RH, Burgering, BM

Nature 2002
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