Reactome | Activated calmodulin dissociates from CaMKII-gamma

Activated calmodulin dissociates from CaMKII-gamma

Stable Identifier

R-HSA-9618834

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        Activated calmodulin dissociates from CaMKII-gamma (Homo sapiens)

General

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Activated calmodulin dissociates from CaMKII-gamma

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In the nucleus, activated calmodulin (CALM1:4xCa2+) dissociates from CaMKII-gamma (p-T287-CAMK2G dodecamer) (Ma et al. 2014, Cohen et al. 2018).

Participants

Input

p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Output

Participates

as an event of

Inferred From

Activated calmodulin dissociates from CaMKII gamma (Rattus norvegicus)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Orlic-Milacic, M (2018-09-12)

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