Reactome | CaMKK binds activated calmodulin in the nucleus

CaMKK binds activated calmodulin in the nucleus

Stable Identifier

R-HSA-9618863

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CaMKK binds activated calmodulin in the nucleus (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK binds activated calmodulin in the nucleus (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK binds activated calmodulin in the nucleus (Homo sapiens)

General

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CaMKK binds activated calmodulin in the nucleus

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Two isoforms of CaMKK, CAMKK1 (CaMKK alpha) and CAMKK2 (CaMKK beta) are expressed in the brain and involved in signaling downstream of the NMDA receptor (Schmitt et al. 2005, Mairet-Coello et al. 2013). CAMKK1 (Lee et al. 2010) and CAMKK2 (Kylarova et al. 2018) become catalytically active upon binding to the calcium-bound calmodulin (CALM1:4xCa2+). Calcium-bound calmodulin needs to translocate to the nucleus for CaMKK activation that precedes CAMK4 phosphorylation in glutamatergic neurons (Ma et al. 2014).

Participants

Input

Output

CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Participates

as an event of

Inferred From

Camkk1 binds activated calmodulin in the nucleus (Homo sapiens)

CAMKK2 binds activated calmodulin in the nucleus (Homo sapiens)

Authored

Mahajan, SS (2009-10-29)

Reviewed

Tukey, D (2009-11-18)

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Orlic-Milacic, M (2018-09-12)

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