Reactome | CaMKK phosphorylates CAMK4

CaMKK phosphorylates CAMK4

Stable Identifier

R-HSA-9619125

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKK phosphorylates CAMK4 (Homo sapiens)

General

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Activated CaMKKs, CAMKK1 (CaMKK-alpha) and CAMKK2 (CaMKK-beta), phosphorylate calmodulin-bound CAMK4 (CaMKIV) on evolutionarily conserved threonine residue T200 (Chatila et al. 1996, Anderson et al. 1998, Tokumitsu et al. 2004).

Participants

Input

Output

Participates

as an event of

Catalyst Activity

calmodulin-dependent protein kinase activity of p-CaMKK:CALM1:4xCa2+ [nucleoplasm]

Physical Entity

p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Homo sapiens)

Activity

calmodulin-dependent protein kinase activity (GO:0004683)

Inferred From

Camkk1 phosphorylates Camk4 (Rattus norvegicus)

Camkk2 phosphorylates CAMK4 (Homo sapiens)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Orlic-Milacic, M (2018-09-14)

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