Reactome | CAMK4 binds KPNA2

CAMK4 binds KPNA2

Stable Identifier

R-HSA-9619127

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CAMK4 binds KPNA2 (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CAMK4 (CaMKIV) forms a complex with KPNA2 (Importin alpha-1). Importin beta is not required for the formation of this complex, but interferes with CAMK4 binding to KPNA2 (Kotera et al. 2005).

Participants

Input

Output

CAMK4:KPNA2 [cytosol] (Homo sapiens)

Participates

as an event of

Inferred From

Camk4 binds Kpna2 (Mus musculus)

Authored

Orlic-Milacic, M (2018-10-10)

Reviewed

Hansen, KB (2018-11-02)

Yi, F (2018-11-02)

Created

Orlic-Milacic, M (2018-09-14)

Cite Us!