Reactome | CAMK1 [cytosol]

CAMK1 [cytosol]

Stable Identifier

R-HSA-9619207

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calcium/calmodulin-dependent protein kinase type 1 ecNumber2.7.11.17/ecNumber, KCC1A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P42858

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Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        Activation of RAC1 downstream of NMDARs (Homo sapiens)
        
        CAMK1 binds calmodulin (Homo sapiens)
        
        CAMK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14012 CAMK1

Gene Names

CAMK1

Chain

chain:1-370

Reference Genes

BioGPS Gene:8536 CAMK1

COSMIC (genes):CAMK1 CAMK1

CTD Gene:8536 CAMK1

dbSNP Gene:8536 CAMK1

ENSEMBL:ENSG00000134072 CAMK1

ENSEMBL_homo_sapiens_GENE:ENSG00000134072.11 CAMK1

HGNC:1459 CAMK1

KEGG Gene (Homo sapiens):8536 CAMK1

Monarch:8536 CAMK1

NCBI Gene:8536 CAMK1

OMIM:604998 CAMK1

UCSC:Q14012 CAMK1

Reference Transcript

RefSeq:NM_003656.4 CAMK1

Other Identifiers

11719228_a_at

16950551

204392_PM_at

204392_at

251_at

2662332

2662333

2662335

2662338

2662339

2662340

2662342

2662343

2662345

2662346

2662347

2662349

2662350

2662352

2662353

8085206

8536

A_23_P121215

GE79999

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006886

GO:0006913

GO:0007049

GO:0007165

GO:0007399

GO:0008152

GO:0010976

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0032091

GO:0032880

GO:0034330

GO:0035556

GO:0036211

GO:0043226

GO:0043393

GO:0045944

GO:0046827

GO:0048856

GO:0051147

GO:0051149

GO:0051835

GO:0060143

GO:0060999

GO:0071902

GO:0106310

GO:0140096

HMNXSV003033045

ILMN_2140990

L41816_at

PH_hs_0028643

TC03001149.hg

g4580415_3p_at

Participates

as a component of

CAMK1:CALM1:4xCa2+ [cytosol] (Homo sapiens)

as an input of

CAMK1 binds calmodulin (Homo sapiens)

Other forms of this molecule

p-T177-CAMK1 [cytosol]

Inferred To

CAMK1 [cytosol] (Bos taurus)

CAMK1 [cytosol] (Caenorhabditis elegans)

CAMK1 [cytosol] (Canis familiaris)

CAMK1 [cytosol] (Dictyostelium discoideum)

CAMK1 [cytosol] (Drosophila melanogaster)

CAMK1 [cytosol] (Gallus gallus)

CAMK1 [cytosol] (Mus musculus)

CAMK1 [cytosol] (Plasmodium falciparum)

CAMK1 [cytosol] (Rattus norvegicus)

CAMK1 [cytosol] (Saccharomyces cerevisiae)

CAMK1 [cytosol] (Sus scrofa)

CAMK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003647.1

ZINC - World Drugs

KCC1A_HUMAN

Guide to Pharmacology - Targets

1952

OpenTargets

ENSG00000134072

ZINC - FDA approved

KCC1A_HUMAN

ZINC - Substances

KCC1A_HUMAN

ZINC - Biogenic

KCC1A_HUMAN

ZINC target

Q14012

PRO

Q14012

PDB

4FG9, 4FG8, 4FG7, 4FGB

ZINC - Investigational

KCC1A_HUMAN

HPA

ENSG00000134072-CAMK1

GeneCards

Q14012

Ensembl

ENSG00000134072, ENST00000256460, ENSP00000256460

Pharos - Targets

Q14012

ZINC - Predictions - Purchasable

KCC1A_HUMAN

HMDB Protein

HMDBP01321

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.718	12
UniProt:Q14005-2 Q140052			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:Q8IU85 KCC1D			0.499	2