Activation of RAC1 downstream of NMDARs

Stable Identifier
R-HSA-9619229
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Activation of RAC1 downstream of NMDARs
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Activation of calcium/calmodulin-dependent kinase kinases, CaMKKs (CAMKK1 and CAMKK2), upon calcium influx through activated NMDA receptors, leads to activation of the cytosolic calcium/calmodulin kinase CaMKI (CAMK1). One of the CAMK1 targets is the RAC1 guanine nucleotide exchange factor ARHGEF7 (beta-Pix). Activation of RAC1 is involved in NMDA-receptor triggered synaptogenesis (Saneyoshi et al. 2008).
Literature References
PubMed ID Title Journal Year
18184567 Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex

Saneyoshi, T, Wayman, G, Fortin, D, Davare, M, Hoshi, N, Nozaki, N, Natsume, T, Soderling, TR

Neuron 2008
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Events
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as an event of
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Orthologous Events
Activation of RAC1 downstream of NMDARs (Bos taurus)
Activation of RAC1 downstream of NMDARs (Caenorhabditis elegans)
Activation of RAC1 downstream of NMDARs (Canis familiaris)
Activation of RAC1 downstream of NMDARs (Drosophila melanogaster)
Activation of RAC1 downstream of NMDARs (Mus musculus)
Activation of RAC1 downstream of NMDARs (Rattus norvegicus)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-14)
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