ERKs phosphorylate RSKs

Stable Identifier
R-HSA-9619843
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAP kinases/ERKs (MAPK1 and MAPK3), activated downstream of RAS signaling, activate RSKs by phosphorylating conserved serine and threonine residues in the linker region and the C-terminal kinase domain (CTKD). In the linker region of RPS6KA1 (RSK1), ERKs phosphorylate threonine residue T359 and serine residue S363. In the CTKD of RPS6KA1, ERKs phosphorylate threonine residue T573 (Dalby et al. 1998, Roux et al. 2003).

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hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T,Y MAPK dimers [cytosol]
Physical Entity
Activity
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