Long-term potentiation

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R-HSA-9620244
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Homo sapiens
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In long-term potentiation (LTP), involved in learning and memory, a brief period of synaptic activity induces a lasting increase in the strength of the synapse. LTP is initiated by NMDA receptor-mediated activation of calcium/calmodulin-dependent protein kinase II (CaMKII), followed by binding of CaMKII to the NMDA receptor and CaMKII-mediated phosphorylation of AMPA receptor subunits (reviewed by Lisman et al. 2012 and Luscher and Malenka 2012).

Literature References
PubMed ID Title Journal Year
22510460 NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD)

L├╝scher, C, Malenka, RC

Cold Spring Harb Perspect Biol 2012
22334212 Mechanisms of CaMKII action in long-term potentiation

Lisman, J, Yasuda, R, Raghavachari, S

Nat. Rev. Neurosci. 2012
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