BTG1 gene expression is stimulated by FOXO3

Stable Identifier
R-HSA-9620915
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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BTG1 gene expression is stimulated by FOXO3
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Transcription of the BTG1 gene, encoding antiproliferative Protein BTG1 is directly stimulated by FOXO3 (Bakker et al. 2004, Bakker et al. 2007, Wang et al. 2015). BTG1 inhibits the outgrowth of erythroid colonies and promotes maturation of mouse (Bakker et al. 2004) and human (Wang et al. 2015) erythroid cells.
Literature References
PubMed ID Title Journal Year
25843800 Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish

Qi, H, Liu, F, Yang, Y, Zheng, J, Zhang, Q, Wang, S, Zhang, Z, Qu, H, Li, Y, Wang, H, Fang, X

Biochem. Biophys. Res. Commun. 2015
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FOXO3:BTG1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3 [nucleoplasm]
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-09-25)
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