CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1)

Stable Identifier
R-HSA-9622738
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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CAT gene expression is stimulated by FOXO3,FOXO6,(FOXO1)
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Transcription of the CAT gene is directly stimulated by FOXO3 (Rangarajan et al. 2015, Song et al. 2016) and FOXO6 (Kim et al. 2014), and is positively regulated by FOXO1 (Awad et al. 2014, Liao et al. 2016, Guo et al. 2016), although direct regulation by FOXO1 has not been demonstrated. CAT encodes the enzyme catalase, which converts hydrogen peroxide to water and oxygen, thus protecting cells from the oxidative stress.
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Output
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as an event of
This event is regulated
Positively by
Regulator
FOXO3,FOXO6,(FOXO1):CAT gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO3,FOXO6,(FOXO1) [nucleoplasm]
Inferred From
Cat gene expression is stimulated by Foxo3 (Mus musculus)
CAT gene expression is stimulated by Foxo6 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-01)
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