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SIRT3 [nucleoplasm]
Stable Identifier
R-HSA-9622879
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:P31040 SDHA
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes (Homo sapiens)
FOXO3 binds SOD2 gene promoter (Homo sapiens)
SIRT3 [nucleoplasm] (Homo sapiens)
FOXO3,FOXO6,(FOXO1) binds CAT gene promoter (Homo sapiens)
SIRT3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTG7 SIRT3
Gene Names
SIRT3, SIR2L3
Chain
transit peptide:1-, chain:-399
Reference Genes
BioGPS Gene:23410 SIRT3
COSMIC (genes):SIRT3 SIRT3
CTD Gene:23410 SIRT3
dbSNP Gene:23410 SIRT3
ENSEMBL:ENSG00000142082 SIRT3
HGNC:14931 SIRT3
KEGG:hsa:23410 SIRT3
Monarch:23410 SIRT3
NCBI Gene:23410 SIRT3
OMIM:604481 SIRT3
UCSC:Q9NTG7 SIRT3
Reference Transcript
RefSeq:NM_001017524.2 SIRT3
RefSeq:NM_012239.5 SIRT3
RefSeq:XM_017017430.1 SIRT3
Other Identifiers
11722446_a_at
11722447_a_at
11739810_x_at
11739811_a_at
221562_PM_s_at
221562_s_at
221913_PM_at
221913_at
23410
3357786
3357788
3357789
3357790
3357792
3357793
3357794
3357795
3357796
3357798
3357799
3357800
3357801
3357804
3357805
3357806
3357807
3357808
3357810
3357811
3357812
3357813
3357814
3357815
49325_at
49327_PM_at
49327_at
7945357
A_23_P139265
A_24_P85158
A_24_P923684
A_33_P3325068
GE58473
GO:0003677
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0006091
GO:0006325
GO:0006338
GO:0006476
GO:0008270
GO:0009060
GO:0016740
GO:0016787
GO:0017136
GO:0019899
GO:0032024
GO:0032991
GO:0034979
GO:0034983
GO:0043226
GO:0043565
GO:0046872
GO:0051287
GO:0070373
GO:0070403
GO:0140096
GO:1901671
GO:1902553
GO:2000304
GO:2000378
HMNXSV003018178
HMNXSV003049799
Hs.19306.1.S1_3p_s_at
ILMN_1724372
ILMN_1733985
PH_hs_0026684
TC11001228.hg
g13259626_3p_a_at
g13259626_3p_x_at
Participates
as a member of
SIRT1,SIRT3 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
FOXO3 binds SOD2 gene promoter
(Homo sapiens)
FOXO3,FOXO6,(FOXO1) binds CAT gene promoter
(Homo sapiens)
Other forms of this molecule
SIRT3(?-399) [mitochondrial matrix]
Inferred To
SIRT3 [nucleoplasm]
(Bos taurus)
SIRT3 [nucleoplasm]
(Canis familiaris)
SIRT3 [nucleoplasm]
(Gallus gallus)
SIRT3 [nucleoplasm]
(Mus musculus)
SIRT3 [nucleoplasm]
(Rattus norvegicus)
SIRT3 [nucleoplasm]
(Sus scrofa)
Cross References
ZINC - World Drugs
SIR3_HUMAN
Guide to Pharmacology - Targets
2709
OpenTargets
ENSG00000142082
ENSEMBL
ENST00000382743
,
ENST00000529382
,
ENSP00000437216
,
ENSP00000372191
ZINC - FDA approved
SIR3_HUMAN
ZINC - Substances
SIR3_HUMAN
ZINC - Biogenic
SIR3_HUMAN
ZINC target
Q9NTG7
PRO
Q9NTG7
PDB
4BVF
,
8HLW
,
4O8Z
,
4BVE
,
4JSR
,
5Z93
,
8HLY
,
4BN5
,
3GLU
,
4FVT
,
4BN4
,
3GLT
,
4JT9
,
5BWO
,
3GLS
,
4FZ3
,
4C78
,
4HD8
,
4BV3
,
4JT8
,
5D7N
,
5H4D
,
5YTK
,
5BWN
,
6ISO
,
8ANC
,
5Y4H
,
8BBK
,
8CCW
,
4BVG
,
8V2N
,
5Z94
,
5ZGC
,
8HN9
,
8V15
,
8CCZ
,
4C7B
,
4BVB
,
3GLR
,
4BVH
ZINC - Metabolites
SIR3_HUMAN
HPA
ENSG00000142082-SIRT3
Pharos - Targets
Q9NTG7
ZINC - Predictions - Purchasable
SIR3_HUMAN
HMDB Protein
HMDBP08881
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10809 HSPD1
6
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.731
5
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.576
5
UniProt:P28799-2 GRN
0.556
3
UniProt:O60313 OPA1
4
OPA1 [mitochondrial inner membrane]
(R-HSA-8867508)
OPA1(88-194) [mitochondrial inner membrane]
(R-HSA-8867509)
OPA1(195-960) [mitochondrial inner membrane]
(R-HSA-8867513)
OPA1 [mitochondrial inner membrane]
(R-HSA-5333636)
0.544
3
UniProt:P31040 SDHA
2
FAD-SDHA [mitochondrial matrix]
(R-HSA-70983)
SDHA [mitochondrial matrix]
(R-HSA-9854690)
0.527
2
UniProt:Q9BX40 LS14B
0.527
2
UniProt:P00966 ASS1
1
ASS1 [cytosol]
(R-HSA-70574)
0.527
2
UniProt:Q9Y6G3 MRPL42
1
MRPL42 [mitochondrial inner membrane]
(R-HSA-5368237)
0.527
2
UniProt:Q96BQ3 TRI43
0.527
2
UniProt:Q9BYZ8 REG4
0.527
2
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.527
4
UniProt:P25705 ATP5F1A
3
ATP5F1A [mitochondrial matrix]
(R-HSA-164575)
ATP5A1(1-553) [cytosol]
(R-HSA-1267955)
ATP5A1(1-553) [mitochondrial intermembrane space]
(R-HSA-1267978)
0.524
2
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