PCK1 gene expression is stimulated by FOXO1:PPARGC1A

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R-HSA-9623280
Type
Reaction [omitted]
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Homo sapiens
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Based on studies in mice, FOXO1 and PPARGC1A (PGC-1alpha) directly stimulate transcription of the PCK1 gene, encoding a gluconeogenesis enzyme Phosphoenolpyruvate carboxykinase (Puigserver et al. 2003).
FOXO3 (Hall et al. 2000) and FOXO4 (Yang et al. 2002) also directly stimulates PCK1 gene transcription .

Literature References
PubMed ID Title Journal Year
11779849 An mRNA splice variant of the AFX gene with altered transcriptional activity

Yang, Z, Whelan, J, Babb, R, Bowen, BR

J. Biol. Chem. 2002
10913147 Regulation of phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein-1 gene expression by insulin. The role of winged helix/forkhead proteins

Hall, RK, Yamasaki, T, Kucera, T, Waltner-Law, M, O'Brien, R, Granner, DK

J. Biol. Chem. 2000
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