BCL2 mRNA and protein levels increase in response to E2 stimulation in a PKA-dependent manner (Grimaldi et al, 2002; Yune et al, 2008). Levels of phosphorylated CREB1 also increase with estrogen stimulation, however direct binding of phosphorylated CREB to the BCL2 promoter has not been demonstrated. Estrogen-dependent BCL2 expression is also dependent on Sp1 (Dong et al, 1999; Yune et al, 2008; reviewed in Ladikou and Kassi, 2017).
Dong, L, Wang, W, Wang, F, Stoner, M, Reed, JC, Harigai, M, Samudio, I, Kladde, MP, Vyhlidal, C, Safe, S
Yune, TY, Park, HG, Lee, JY, Oh, TH
Grimaldi, CM, Cleary, J, Dagtas, AS, Moussai, D, Diamond, B
Ladikou, EE, Kassi, E
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