Reactome | BCL gene expression downstream of ESR1

BCL gene expression downstream of ESR1

Stable Identifier

R-HSA-9623999

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm, mitochondrial outer membrane

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BCL2 mRNA and protein levels increase in response to E2 stimulation in a PKA-dependent manner (Grimaldi et al, 2002; Yune et al, 2008). Levels of phosphorylated CREB1 also increase with estrogen stimulation, however direct binding of phosphorylated CREB to the BCL2 promoter has not been demonstrated. Estrogen-dependent BCL2 expression is also dependent on Sp1 (Dong et al, 1999; Yune et al, 2008; reviewed in Ladikou and Kassi, 2017).

Literature References

PubMed ID	Title	Journal	Year
10542244	Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells Dong, L, Wang, W, Wang, F, Stoner, M, Reed, JC, Harigai, M, Samudio, I, Kladde, MP, Vyhlidal, C, Safe, S	J. Biol. Chem.	1999
18785877	Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation Yune, TY, Park, HG, Lee, JY, Oh, TH	J. Neurotrauma	2008
12070310	Estrogen alters thresholds for B cell apoptosis and activation Grimaldi, CM, Cleary, J, Dagtas, AS, Moussai, D, Diamond, B	J. Clin. Invest.	2002
27557932	The emerging role of estrogen in B cell malignancies Ladikou, EE, Kassi, E	Leuk. Lymphoma	2017