Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
EGF-like ligands [extracellular region]
Stable Identifier
R-HSA-9624194
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Signaling by EGFR in Cancer (Homo sapiens)
Signaling by Overexpressed Wild-Type EGFR in Cancer (Homo sapiens)
Inhibition of Signaling by Overexpressed EGFR (Homo sapiens)
Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)
EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
E2-mediated FOS gene expression (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PTK2 autophosphorylates downstream of EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PTK2 binds activated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR autophosphorylation (Homo sapiens)
EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR binds EGF ligand (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR dimerization (Homo sapiens)
EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR downregulation (Homo sapiens)
Assembly of EGFR complex in clathrin-coated vesicles (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Binding of CBL to EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CBL ubiquitinates Sprouty (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CBL-mediated ubiquitination of CIN85 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Homo sapiens)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR non-clathrin mediated endocytosis (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR phosphorylates EPS15 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Localization of CBL:GRB2 to the membrane (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PTPN3 dephosphorylates EPS15 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Sprouty sequesters CBL away from active EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Ubiquitination of stimulated EGFR (CBL) (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Ubiquitination of stimulated EGFR (CBL:GRB2) (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR interacts with phospholipase C-gamma (Homo sapiens)
Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Dephosphorylation of PAG by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
GAB1 phosphorylation by EGFR kinase (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Phospho-EGFR (-Y1016) dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
GRB2 events in EGFR signaling (Homo sapiens)
GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Phosphorylation of EGFR by SRC kinase (Homo sapiens)
EGF-like ligands:EGFR dimer [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SHC1 events in EGFR signaling (Homo sapiens)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
BAR domain proteins recruit dynamin (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Clathrin recruits PIK3C2A (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
CLASP proteins:cargo [plasma membrane] (Homo sapiens)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
ubiquitinated cargo [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands [extracellular region] (Homo sapiens)
Participants
members
EGF [extracellular region]
(Homo sapiens)
TGFA(24-98) [extracellular region]
(Homo sapiens)
AREG(101-187) [extracellular region]
(Homo sapiens)
EPGN(23-154) [extracellular region]
(Homo sapiens)
BTC(32-111) [extracellular region]
(Homo sapiens)
EREG(60-108) [extracellular region]
(Homo sapiens)
HBEGF(63-148) [extracellular region]
(Homo sapiens)
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Homo sapiens)
EGF-like ligands:Phospho-EGFR (- Y992) [plasma membrane] (Homo sapiens)
EGFR:EGF-like ligands [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
as an input of
EGFR binds EGF ligand (Homo sapiens)
Inferred To
EGF-like ligands [extracellular region]
(Bos taurus)
EGF-like ligands [extracellular region]
(Canis familiaris)
EGF-like ligands [extracellular region]
(Danio rerio)
EGF-like ligands [extracellular region]
(Gallus gallus)
EGF-like ligands [extracellular region]
(Mus musculus)
EGF-like ligands [extracellular region]
(Rattus norvegicus)
EGF-like ligands [extracellular region]
(Sus scrofa)
EGF-like ligands [extracellular region]
(Xenopus tropicalis)
Homologues of EGF [extracellular region]
(Caenorhabditis elegans)
Homologues of EGF [extracellular region]
(Drosophila melanogaster)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
