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EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
Stable Identifier
R-HSA-9624425
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-dependent nuclear events downstream of ESR-membrane signaling (Homo sapiens)
E2-mediated FOS gene expression (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PTK2 autophosphorylates downstream of EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PTK2 binds activated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by EGFR (Homo sapiens)
EGFR autophosphorylation (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGFR downregulation (Homo sapiens)
Binding of CBL to EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
CBL binds and ubiquitinates phosphorylated Sprouty (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
CBL ubiquitinates Sprouty (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Localization of CBL:GRB2 to the membrane (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Phosphorylation of CBL (EGFR:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGFR interacts with phospholipase C-gamma (Homo sapiens)
Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGFR activates PLC-gamma1 by phosphorylation (Homo sapiens)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
GAB1 signalosome (Homo sapiens)
Activation of SHP2 through the binding to phospho-Gab1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Dephosphorylation of Gab1 by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Dephosphorylation of PAG by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
GAB1 phosphorylation by EGFR kinase (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SHP2 dephosphorylates Tyr 992 on EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Sustained activation of SRC kinase by SHP2 (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
GRB2 events in EGFR signaling (Homo sapiens)
GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Phosphorylation of EGFR by SRC kinase (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SHC1 events in EGFR signaling (Homo sapiens)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SHC1 phosphorylation by phosphorylated EGFR (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane] (Homo sapiens)
Participants
components
x 2
EGF-like ligands [extracellular region]
(Homo sapiens)
x 2
p-6Y-EGFR [plasma membrane]
(Homo sapiens)
Participates
as a component of
EGF-like ligands:p-6Y-EGFR:GRB2:p-Y627,659-GAB1:SHP2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR dimer:p-Y397 PTK2 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligand:p-6Y-EGFR:p-Y472,771,783,1254-PLCG1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:GAB1 [plasma membrane] (Homo sapiens)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Homo sapiens)
as an input of
Localization of CBL:GRB2 to the membrane (Homo sapiens)
Binding of CBL to EGFR (Homo sapiens)
PTK2 binds activated EGFR (Homo sapiens)
GRB2:SOS1 complex binds to EGF:EGFR complex (Homo sapiens)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Homo sapiens)
Phospholipase C-gamma1 binds to the activated EGF receptor (Homo sapiens)
GRB2:GAB1 binds to phosphorylated EGFR (Homo sapiens)
as an output of
Active PLC-gamma1 dissociates from EGFR (Homo sapiens)
EGFR autophosphorylation (Homo sapiens)
Phosphorylation of EGFR by SRC kinase (Homo sapiens)
Inferred To
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Bos taurus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Caenorhabditis elegans)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Canis familiaris)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Danio rerio)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Drosophila melanogaster)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Gallus gallus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Mus musculus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Rattus norvegicus)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Sus scrofa)
EGF-like ligands:p-6Y EGFR dimer [plasma membrane]
(Xenopus tropicalis)
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