Reactome | AKT-phosphorylated FOXO3 translocates to cytosol

AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier

R-HSA-9624527

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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AKT-phosphorylated FOXO3 translocates to cytosol

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AKT-mediated phosphorylation of FOXO3 downstream of estrogen stimulation promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity (Richards et al, 2002; Brunet et al, 1999; reviewed in Levin, 2005; Burgering, 2008).

Literature References

PubMed ID	Title	Journal	Year
18391968	A brief introduction to FOXOlogy Burgering, BM	Oncogene	2008
10102273	Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME	Cell	1999
11875118	Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins Richards, JS, Sharma, SC, Falender, AE, Lo, YH	Mol. Endocrinol.	2002
15705661	Integration of the extranuclear and nuclear actions of estrogen Levin, ER	Mol. Endocrinol.	2005