AKT-mediated phosphorylation of FOXO3 downstream of estrogen stimulation promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity (Richards et al, 2002; Brunet et al, 1999; reviewed in Levin, 2005; Burgering, 2008).
Burgering, BM
Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME
Richards, JS, Sharma, SC, Falender, AE, Lo, YH
Levin, ER
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