AKT-phosphorylated FOXO3 translocates to cytosol

Stable Identifier
Reaction [omitted]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AKT-mediated phosphorylation of FOXO3 downstream of estrogen stimulation promotes its inactivation and translocation to the cytosol, interfering with its pro-apoptotic transcription factor activity (Richards et al, 2002; Brunet et al, 1999; reviewed in Levin, 2005; Burgering, 2008).

Literature References
PubMed ID Title Journal Year
18391968 A brief introduction to FOXOlogy

Burgering, BM

Oncogene 2008
10102273 Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Brunet, A, Bonni, A, Zigmond, MJ, Lin, MZ, Juo, P, Hu, LS, Anderson, MJ, Arden, KC, Blenis, J, Greenberg, ME

Cell 1999
11875118 Expression of FKHR, FKHRL1, and AFX genes in the rodent ovary: evidence for regulation by IGF-I, estrogen, and the gonadotropins

Richards, JS, Sharma, SC, Falender, AE, Lo, YH

Mol. Endocrinol. 2002
15705661 Integration of the extranuclear and nuclear actions of estrogen

Levin, ER

Mol. Endocrinol. 2005
Participant Of
Orthologous Events
Cite Us!