CEBPA binds CDKN1A (p21)

Stable Identifier
R-HSA-9624668
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CEBPA interacts with CDKN1A (p21), resulting in a cooperative inhibition of CDK2 and cellular proliferation (Harris et al. 2001). CEBPA also increases the cellular abundance of CDKN1A by stabilizing the CDKN1A protein and activating transcription of the CDKN1A gene (Timchenko et al. 1996, Quintana-Bustamante et al. 2012).

Literature References
PubMed ID Title Journal Year
8846917 CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein

Timchenko, NA, Wilde, M, Nakanishi, M, Smith, JR, Darlington, GJ

Genes Dev. 1996
11369759 CCAAT/enhancer-binding protein-alpha cooperates with p21 to inhibit cyclin-dependent kinase-2 activity and induces growth arrest independent of DNA binding

Harris, TE, Albrecht, JH, Nakanishi, M, Darlington, GJ

J. Biol. Chem. 2001
22371011 Overexpression of wild-type or mutants forms of CEBPA alter normal human hematopoiesis

Quintana-Bustamante, O, Lan-Lan Smith, S, Griessinger, E, Reyal, Y, Vargaftig, J, Lister, TA, Fitzgibbon, J, Bonnet, D

Leukemia 2012
Participants
Participant Of
Orthologous Events
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Created