SFTPD 12mer translocates from ER membrane to extracellular region

Stable Identifier
R-HSA-9624778
Type
Reaction [uncertain]
Species
Homo sapiens
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The pulmonary collectins, surfactant proteins A1, A2, A3 and D (SFTPAs, SFTPD 12mer), play important roles in innate host defense by binding and clearing invading microbes from the lung. They also influence surfactant homeostasis, contributing to the physical structures of lipids in the alveoli and to the regulation of surfactant function and metabolism. They are directly secreted from alveolar type II cells into the airway to function as part of the surfactant. The mechanism of secretion is unknown (Andreeva et al. 2007).

Literature References
PubMed ID Title Journal Year
17496061 Regulation of surfactant secretion in alveolar type II cells

Andreeva, AV, Kutuzov, MA, Voyno-Yasenetskaya, TA

Am. J. Physiol. Lung Cell Mol. Physiol. 2007
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