pro-SFTPB translocates from ER membrane to multivesicle body

Stable Identifier
R-HSA-9624789
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Surfactant proteins (SFTPs) are trafficked from the ER membrane to lamellar bodies (LBs) via the multi-vesicle body (MVB). The pro-SFTPs B and C are cleaved here to produce functional SFTPs (Voorhout et al. 1992, Weaver et al. 1992).

Literature References
PubMed ID Title Journal Year
1415726 Intracellular processing of pulmonary surfactant protein B in an endosomal/lysosomal compartment

Voorhout, WF, Veenendaal, T, Haagsman, HP, Weaver, TE, Whitsett, JA, van Golde, LM, Geuze, HJ

Am. J. Physiol. 1992
1636732 Processing of surfactant protein B proprotein by a cathepsin D-like protease

Weaver, TE, Lin, S, Bogucki, B, Dey, C

Am. J. Physiol. 1992
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created