SREBF1 gene expression is inhibited by FOXO1

Stable Identifier
R-HSA-9625346
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SREBF1 gene expression is inhibited by FOXO1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FOXO1 directly represses transcription of the SREBF1 (SREBP1) gene, encoding Sterol regulatory element-binding protein 1, a transcriptional activator required for lipid homeostasis (Deng et al. 2012). FOXO1 binding interferes with recruitment of SREBF1 transcriptional activator NR1H3 (LXRA) to the SREBF1 promoter (Liu et al. 2010). CRY1, a transcriptional target of SREBF1, downregulates FOXO1 protein levels by promoting MDM2-mediated polyubiquitination and degradation of FOXO1 (Jang et al. 2016).
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FOXO1:SREBF1 gene [nucleoplasm] (Homo sapiens)
Active Unit
FOXO1 [nucleoplasm]
Inferred From
Srebf1 gene expression is inhibited by FOXO1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-19)
Cite Us!