SRF and ELK1 bind the FOS gene

Stable Identifier
R-HSA-9625479
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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SRF and ELK1 bind the FOS gene
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SRF and phosphorylated ELK1 bind to sterol response elements (SRE) in the FOS promoter downstream of E2- and growth factor stimulation (Marais et al, 1993; Gille et al, 1995; Duan et al, 2001; reviewed in Treisman, 1995). FOS gene expression downstream of estrogen stimulation occurs in both an ER alpha (ESR1)- and GPER1-dependent fashion (Maggiolini et al, 2004; Vivacqua et al, 2006; Tsai et al, 2013).

Literature References
PubMed ID Title Journal Year
15090535 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells

Maggiolini, M, Vivacqua, A, Fasanella, G, Recchia, AG, Sisci, D, Pezzi, V, Montanaro, D, Musti, AM, Picard, D, Andó, S

J. Biol. Chem. 2004
24039841 Estradiol and tamoxifen induce cell migration through GPR30 and activation of focal adhesion kinase (FAK) in endometrial cancers with low or without nuclear estrogen receptor α (ERα)

Tsai, CL, Wu, HM, Lin, CY, Lin, YJ, Chao, A, Wang, TH, Hsueh, S, Lai, CH, Wang, HS

PLoS ONE 2013
8386592 The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

Marais, R, Wynne, J, Treisman, R

Cell 1993
7588619 Journey to the surface of the cell: Fos regulation and the SRE

Treisman, R

EMBO J. 1995
11145955 Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1

Duan, R, Xie, W, Burghardt, RC, Safe, S

J. Biol. Chem. 2001
7889942 ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation

Gille, H, Kortenjann, M, Thomae, O, Moomaw, C, Slaughter, C, Cobb, MH, Shaw, PE

EMBO J 1995
16835357 17beta-estradiol, genistein, and 4-hydroxytamoxifen induce the proliferation of thyroid cancer cells through the g protein-coupled receptor GPR30

Vivacqua, A, Bonofiglio, D, Albanito, L, Madeo, A, Rago, V, Carpino, A, Musti, AM, Picard, D, Andó, S, Maggiolini, M

Mol. Pharmacol. 2006
Participants
Input
Output
Participant Of
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Authored
Rothfels, K  (2018-12-15)
Reviewed
Levin, ER  (2019-02-20)
Created
Rothfels, K  (2018-10-19)
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