FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter

Stable Identifier
R-HSA-9625510
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FOXO1 and p-2S-SMAD2/3:SMAD4 bind MSTN gene promoter
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Based on studies in mice, FOXO1 and the p-2S-SMAD2/3:SMAD4 complex bind the promoter of the MSTN gene, encoding myostatin (Allen and Unterman 2007). FOXO3 and glucocorticoid receptor (NR3C1, also known as GR) were reported to bind MSTN promoter in porcine cells (Jia et al. 2016).
Participants
Input
Output
Participates
as an event of
Inferred From
FOXO1 and p-2S-Smad2/3:Smad4 bind Mstn gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-23)
Reviewed
Donlon, T  (2018-10-23)
Created
Orlic-Milacic, M  (2018-10-20)
Cite Us!