SIRT1 deacetylates FOXO1

Stable Identifier
R-HSA-9626962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylation increases FOXO1-mediated upregulation of SOD2 and CDKN1B (Diatoku et al. 2004). SIRT-dependent deacetylation leads to retention of FOXO1 in the nucleus (Frescas et al. 2005).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein deacetylase activity of SIRT1 [nucleoplasm]
Physical Entity
Activity
Inferred From
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Reviewed
Created
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