Regulation of the apoptosome activity

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R-HSA-9627069
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Pathway
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Homo sapiens
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Apoptosis is a controlled process of cell death, which must be tightly regulated to ensure that potentially dangerous cells are efficiently removed, while cells that are transiently stressed by environmental conditions can recover and survive (Bratton SB & Salvesen GS 2010). Defects in the regulation of apoptosis have been associated with the pathogenesis of disease states such as neurodegeneration and cancer (Favaloro B et al. 2012). The mitochondrial or intrinsic apoptotic pathway is regulated at multiple steps, including apoptosome formation and caspase‑9 activation.

Literature References
PubMed ID Title Journal Year
20844150 Regulation of the Apaf-1-caspase-9 apoptosome

Bratton, SB, Salvesen, GS

J. Cell. Sci. 2010
28192157 Apaf-1: Regulation and function in cell death

Shakeri, R, Kheirollahi, A, Davoodi, J

Biochimie 2017
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Orthologous Events
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BioModels Database
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