SEPT4 binds XIAP

Stable Identifier
R-HSA-9627369
Type
Reaction [binding]
Species
Homo sapiens
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SEPT4 (known also as ARTS, an apoptosis-related protein in the TGF-beta signaling pathway) is a pro-apoptotic mitochondrial protein (Gottfried Y et al. 2004). SEPT4 is an unique member of the septin family which functions as a tumor suppressor. SEPT4 promotes apoptosis through binding and antagonizing inhibitor of apoptosis (IAP) proteins and specifically X linked IAP (XIAP) (Gottfried Y et al. 2004). NMR and fluorescence spectroscopy showed that the C-terminal domain (CTD) of SEPT4 directly binds BIR3 domain of XIAP. The BIR3 interacting region in SEPT4 CTD was mapped to SEPT4 residues 266 - 274, which are the nine C-terminal residues in the protein (Bornstein B et al. 2011; Reingewertz TH et al. 2011).

Literature References
PubMed ID Title Journal Year
21695558 ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists

Bornstein, B, Gottfried, Y, Edison, N, Shekhtman, A, Lev, T, Glaser, F, Larisch, S

Apoptosis 2011
21949740 Mechanism of the interaction between the intrinsically disordered C-terminus of the pro-apoptotic ARTS protein and the Bir3 domain of XIAP

Reingewertz, TH, Shalev, DE, Sukenik, S, Blatt, O, Rotem-Bamberger, S, Lebendiker, M, Larisch, S, Friedler, A

PLoS ONE 2011
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