Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation

Stable Identifier
R-HSA-9628444
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation
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E3 ubiquitin ligase TRAF6 generates free K63 -linked polyubiquitin chains that non-covalently associate with ubiquitin receptors of TAB2/TAB3 regulatory proteins of the TAK1 complex, leading to the activation of the TAK1 kinase.
Literature References
PubMed ID Title Journal Year
19675569 Direct activation of protein kinases by unanchored polyubiquitin chains

Adhikari, A, Zeng, W, Chen, ZJ, Pineda, G, Sun, L, Chen, X, Jiang, X, Xia, ZP

Nature 2009
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Catalyst Activity

ubiquitin-protein transferase activity of viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane]

Physical Entity
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Shamovsky, V  (2009-12-16)
Reviewed
Gillespie, ME  (2010-03-02)
Created
Shamovsky, V  (2018-11-09)
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