Reactome | JMJD7 dimer hydroxlates a lysine residue of DRG1

JMJD7 dimer hydroxlates a lysine residue of DRG1

Stable Identifier

R-HSA-9629591

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2-oxoglutarate + L-lysyl-(protein) + O2 => (3S)-3-hydroxy-L-lysyl-(protein) + CO2 + succinate

ReviewStatus

3/5

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JMJD7 dimer hydroxlates a lysine residue of DRG1

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JMJD7 (JmjC domain-containing protein 7) catalyzes the 3-hydroxlation of a lysine residue of DRG1 (developmentally-regulated GTP-binding protein 1). The catalytically active form of JMJD7 is a dimer, each monomeric subunit of which is associated with a Fe2+ ion (Markolovic et al. 2018). DRG1 occurs as a heterdimer with one molecule of ZC3H15 (DFRP1) (Ishikawa et al. 2005, 2009).

Literature References

PubMed ID	Title	Journal	Year
19819225	Independent stabilizations of polysomal Drg1/Dfrp1 complex and non-polysomal Drg2/Dfrp2 complex in mammalian cells Semba, K, Ishikawa, K, Akiyama, T, Ito, K, Inoue, J	Biochem. Biophys. Res. Commun.	2009
15676025	Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2 Semba, K, Ishikawa, K, Azuma, S, Ikawa, S, Inoue, J	Genes Cells	2005
29915238	The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases Eaton, CD, Abboud, MI, Katz, MJ, Hall, C, Markolovic, S, Coleman, ML, Fischer, R, Ge, W, Benesch, JLP, Leśniak, RK, Zhuang, Q, Struwe, WB, Wappner, P, Yang, M, Chowdhury, R, Davis, S, Konietzny, R, Kessler, BM, Cockman, ME, Ratcliffe, PJ, Schofield, CJ, McNeil, HE, Wilkins, SE	Nat. Chem. Biol.	2018