Reactome | DTNB [plasma membrane]

DTNB [plasma membrane]

Stable Identifier

R-HSA-9630734

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Dystrobrevin beta, DTNB_HUMAN

Locations in the PathwayBrowser

Expand all

Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
    - DGC complex binds AGRN and HSPG2 (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
    - DGC complex binds laminins (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
    - DGC:laminin complex binds F-actin (Homo sapiens)
      - DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins [plasma membrane] (Homo sapiens)
        
        DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
    - Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC (Homo sapiens)
      - DGC [plasma membrane] (Homo sapiens)
        
        DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)
      - DTN:SNT complex [plasma membrane] (Homo sapiens)
        
        DTNA,B [plasma membrane] (Homo sapiens)
        
        DTNB [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60941 DTNB

Gene Names

DTNB

Chain

chain:1-627

Reference Genes

BioGPS Gene:1838 DTNB

COSMIC (genes):DTNB DTNB

CTD Gene:1838 DTNB

dbSNP Gene:1838 DTNB

ENSEMBL:ENSG00000138101 DTNB

HGNC:3058 DTNB

KEGG:hsa:1838 DTNB

Monarch:1838 DTNB

NCBI Gene:1838 DTNB

OMIM:602415 DTNB

UCSC:O60941 DTNB

Reference Transcript

Participates

as a member of

DTNA,B [plasma membrane] (Homo sapiens)

Inferred To

Dyb [plasma membrane] (Drosophila melanogaster)

dtnb [plasma membrane] (Xenopus tropicalis)

dyb-1 [plasma membrane] (Caenorhabditis elegans)

DTNB [plasma membrane] (Bos taurus)

DTNB [plasma membrane] (Canis familiaris)

DTNB [plasma membrane] (Sus scrofa)

Dtnb [plasma membrane] (Mus musculus)

Dtnb [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001243232.1, NP_001307864.1, NP_001307863.1, NP_001307865.1, NP_001243237.1, NP_149159.2, NP_068707.1, NP_899205.1, NP_899204.1, NP_149160.1, NP_001307862.1, NP_001307861.1

OpenTargets

ENSG00000138101

ENSEMBL

ENSP00000384767, ENST00000407038, ENSG00000138101, ENST00000405222, ENSP00000384787, ENST00000406818, ENST00000407661, ENST00000404103, ENSP00000385193, ENSP00000384084, ENSP00000385482

HPA

ENSG00000138101-DTNB

GeneCards

DTNB

PRO

O60941

Pharos - Targets

O60941

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11532 DMD	1	DMD [cytosol] (R-HSA-390567)	0.891	10
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.742	5
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.696	5
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.666	4
UniProt:P46939 UTRN	1	UTRN [cytosol] (R-HSA-5216039)	0.564	2
UniProt:Q96EV8 DTNBP1	1	DTNBP1 [cytosol] (R-HSA-429819)	0.556	3
UniProt:Q9HAP6 LIN7B	2	LIN7B [transport vesicle membrane] (R-HSA-9610415) LIN7B [plasma membrane] (R-HSA-5216107)	0.527	2

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