Diseases of Cellular Senescence

Stable Identifier
R-HSA-9630747
Type
Pathway
Species
Homo sapiens
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Cellular senescence plays an important role in normal aging, as well as in age-related diseases. Impaired cellular senescence contributes to malignant transformation and cancer development. Presence of an excessive number of senescent cells that are not cleared by the immune system, however, promotes tissue inflammation and creates a microenvironment suitable for growth of neighboring malignant cells. Besides cancer, senescence is also involved in atherosclerosis, osteoarthritis and diabetes (Childs et al. 2015, He and Sharpless 2017).

Literature References
PubMed ID Title Journal Year
26646499 Cellular senescence in aging and age-related disease: from mechanisms to therapy

Childs, BG, Durik, M, Baker, DJ, van Deursen, JM

Nat. Med. 2015
28575665 Senescence in Health and Disease

He, S, Sharpless, NE

Cell 2017
Participants
Participant Of
hasEvent
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
Created