Reactome | RPL27A [nucleoplasm]

RPL27A [nucleoplasm]

Stable Identifier

R-HSA-9630984

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

60S ribosomal protein L27a, RL27A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P46776 RPL27A

Gene Names

RPL27A

Chain

chain:1-148

Reference Genes

BioGPS Gene:6157 RPL27A

COSMIC (genes):RPL27A RPL27A

CTD Gene:6157 RPL27A

dbSNP Gene:6157 RPL27A

ENSEMBL:ENSG00000166441 RPL27A

HGNC:10329 RPL27A

KEGG:hsa:6157 RPL27A

Monarch:6157 RPL27A

NCBI Gene:6157 RPL27A

OMIM:603637 RPL27A

UCSC:P46776 RPL27A

Reference Transcript

RefSeq:NM_000990.4 RPL27A

Other Identifiers

11736810_at

11757154_at

11757155_x_at

11757157_at

11757158_x_at

16721715

16721732

17118780

203034_3p_s_at

203034_PM_s_at

203034_s_at

223707_PM_at

223707_at

2862831

2980367

2980370

2980371

32436_at

3319588

3319589

3319590

3319591

3319592

3319593

3319594

3319595

3319596

3319597

3319598

3319599

3319600

3319601

3319602

3319603

3319604

3319605

3319606

3319607

3319608

3319609

3319610

3319611

3319612

3319614

3319615

3319616

3319617

3319618

3319619

3319620

3319624

3319626

6157

77583_at

7938286

7938291

7938293

7938295

81234_at

8180404

83719_at

A_14_P100322

A_14_P114318

A_21_P0000265

A_21_P0000332

A_23_P203577

A_23_P416305

GE79837

GE84889

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0016020

GO:0022625

GO:0022626

GO:0043226

GO:1990904

HMNXSV003013118

HMNXSV003013268

HMNXSV003025532

HMNXSV003043799

ILMN_1713086

PH_hs_0029866

PH_hs_0037283

PH_hs_0040287

RNA33514|snoRNA_scaRNA_110_131

RNA33519|snoRNA_scaRNA_115_130

TC11000161.hg

TC11003497.hg

TC11003498.hg

U14968_at

g13279118_3p_at

g4506624_3p_a_at

g4506624_3p_x_at

Participates

as an input of

RIOX2Fe2+ hydroxylates a histidine residue of RPL27A (Homo sapiens)

Other forms of this molecule

RPL27A [cytosol]

3OHH39-RPL27A [nucleoplasm]

Inferred To

Rpl27al3 [nucleoplasm] (Rattus norvegicus)

LOC106559080 [nucleoplasm] (Canis familiaris)

RpL27A [nucleoplasm] (Drosophila melanogaster)

rpl2802 [nucleoplasm] (Schizosaccharomyces pombe)

RPL27A [nucleoplasm] (Bos taurus)

RPL27A [nucleoplasm] (Canis familiaris)

RPL27A [nucleoplasm] (Gallus gallus)

RPL27A [nucleoplasm] (Plasmodium falciparum)

RPL27A [nucleoplasm] (Sus scrofa)

rpl27a [nucleoplasm] (Dictyostelium discoideum)

Homologues of RPL27A [nucleoplasm] (Canis familiaris)

Homologues of RPL27A [nucleoplasm] (Rattus norvegicus)

Homologues of RPL27A [nucleoplasm] (Schizosaccharomyces pombe)

Rpl27a [nucleoplasm] (Mus musculus)

Rpl27a [nucleoplasm] (Rattus norvegicus)

rpl2801 [nucleoplasm] (Schizosaccharomyces pombe)

RPL28 [nucleoplasm] (Saccharomyces cerevisiae)

rpl-27a [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000981.1

OpenTargets

ENSG00000166441

ENSEMBL

ENSP00000346015, ENST00000314138

HPA

ENSG00000166441-RPL27A

PRO

P46776

Pharos - Targets

P46776

GlyGen

P46776

PDB

8FKU, 8FL9, 8FKV, 8IR1, 8IR3, 8IPD, 8OJ8, 6ZMO, 8IDY, 8FLE, 8IFD, 6XA1, 4BXF, 6IP5, 6IP6, 6LU8, 5T2C, 6Y2L, 6LSS, 8FKY, 6Y6X, 6Z6L, 6ZM7, 8FKS, 8G5Z, 6LSR, 8OJ0, 8FKQ, 8FKT, 6OLG, 8JDK, 8FLA, 8JDM, 8Y0X, 7OW7, 8A3D, 8OHD, 7BHP, 8IPX, 8FKR, 8G60, 8OJ5, 8G5Y, 8INE, 6OLZ, 8G61, 8IFE, 8G6J, 5LKS, 8FKW, 8FKX, 8FL6, 8IDT, 8FL7, 8FKP, 8FLC, 6LQM, 6Y57, 6IP8, 6OM7, 5AJ0, 6W6L, 8QOI, 6QZP, 6ZME, 6OLI, 6Z6N, 8FLD, 7XNY, 8INK, 8FLB, 6OM0, 8QFD, 6Y0G, 7F5S, 8FKZ, 7QVP, 4V6X, 8FL4, 6Z6M, 8FL2, 8GLP, 8IPY, 8INF, 6OLE, 8JDL, 8JDJ, 8FL3, 8Y0W, 6ZMI, 6OLF, 8FLF, 4UG0, 8IE3

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.615	3
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089)	0.564	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:P13984 GTF2F2	1	GTF2F2 [nucleoplasm] (R-HSA-65567)	0.524	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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