Reactome | UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

Stable Identifier

R-HSA-9632038

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP

ReviewStatus

5/5

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UGT1A1 tetramer transfers GlcA from UDP-GlcA to BMG to form BDG

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The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). The monomeric forms of UGT1A1 (Bilirubin UDP-glucuronyltransferase 1) only conjugates the first step of bilirubin conjugation to form the monoglucuronide. A tetrameric form of UGT1A1 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuronide (BDG) conjugates respectively (Peters & Jansen 1986, Gorden et al. 1983, Choudhury et al. 1981, Fevery et al. 1971).

Literature References

PubMed ID	Title	Journal	Year
4639028	Bilirubin conjugates in bile of man and rat in the normal state and in liver disease Michiels, R, Van, Damme B, Heirwegh, KP, Fevery, J, De Groote, J	J Clin Invest	1972
6654901	The hepatic microsomal formation of bilirubin diglucuronide Goresky, CA, Gordon, ER, Sommerer, U	J Biol Chem	1983
6796486	Bilirubin mono- and diglucuronide formation by human liver in vitro: assay by high-pressure liquid chromatography Shouval, R, Wu, G, Chowdhury, JR, Chowdhury, NR, Arias, IM	Hepatology	1981
3082969	Microsomal UDP-glucuronyltransferase-catalyzed bilirubin diglucuronide formation in human liver Jansen, PL, Peters, WH	J Hepatol	1986