p16INK4A W110* [cytosol]

Stable Identifier
R-HSA-9632585
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p16INK4A W110TER, p16INK4A Trp110TER, p16INK4A Trp110*, CDKN2A W110TER, CDKN2A Trp110TER, CDKN2A W110*, CDKN2A Trp110*
p16INK4A W110* [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9354451 CDKN2A/p16 is inactivated in most melanoma cell lines

Castellano, M, Pollock, PM, Walters, MK, Sparrow, LE, Down, LM, Gabrielli, BG, Parsons, PG, Hayward, NK

Cancer Res. 1997
External Reference Information
External Reference
Gene Names
CDKN2A, CDKN2, MTS1
Chain
chain:1-156
Other Identifiers
0002570204
0005130288
0101400494
1029
11718293_a_at
1713_s_at
207039_at
209644_x_at
211156_at
3201444
3201445
3201446
3201447
3201448
3201450
3201451
3201457
3201458
3201459
3201460
3201461
3201464
3201465
3201466
3201467
3201468
3201469
3201470
3201477
3201478
3201483
3201485
73132_r_at
8160441
A_23_P43484
A_23_P43490
A_33_P3411628
GE59038
GO:0000082
GO:0000278
GO:0001953
GO:0003674
GO:0003723
GO:0004861
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0007049
GO:0007050
GO:0007155
GO:0007165
GO:0007265
GO:0007568
GO:0008134
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009058
GO:0016301
GO:0016310
GO:0019899
GO:0019901
GO:0022607
GO:0030234
GO:0030308
GO:0032088
GO:0034393
GO:0034641
GO:0035985
GO:0035986
GO:0040007
GO:0042326
GO:0043226
GO:0045736
GO:0045892
GO:0051059
GO:0051276
GO:0090398
GO:0090399
GO:2000111
GO:2000134
GO:2000774
ILMN_1717714
ILMN_1757255
PH_hs_0019731
U26727_at
g1353569_3p_a_at
g1353569_3p_x_at
g4206166_3p_a_at
g4502748_3p_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-tryptophan 110 replaced with unknown
Coordinate
110
PsiMod
A protein modification that effectively removes or replaces an L-tryptophan.
Disease
Name Identifier Synonyms
sebaceous carcinoma 4840 malignant Sebaceous tumor, malignant neoplasm of sebaceous gland
non-small cell lung carcinoma 3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
vulva squamous cell carcinoma 2101 squamous cell carcinoma of vulva, Vulvar Epidermoid carcinoma, vulvar squamous cell carcinoma
thyroid carcinoma 3963 head and neck cancer, Thyroid
fibrous histiocytoma 4415 benign fibrous histiocytoma, fibrous Histiocytoma, Fibroxanthoma
thymus cancer 3277 thymus cancer, thymic neoplasm, Thymus cancer, Thymic tumor, neoplasm of thymus (disorder)
head and neck squamous cell carcinoma 5520 carcinoma of the head and neck, squamous cell carcinoma of the head and neck
larynx cancer 2596
bladder carcinoma 4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
oral squamous cell carcinoma 0050866 mouth squamous cell carcinoma
kidney cancer 263 malignant neoplasm of kidney except pelvis, malignant tumour of kidney, renal cancer
skin squamous cell carcinoma 3151 Epidermoid skin carcinoma, squamous cell carcinoma of skin (disorder)
lung squamous cell carcinoma 3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
Barrett's esophagus 9206 Barrett's ulcer of esophagus, Barrett's oesophagus, ulcerative esophagitis, Barrett's esophagus with esophagitis, Barrett esophagus, CLE, Barretts syndrome
esophagus squamous cell carcinoma 3748 SCC of esophagus, squamous cell carcinoma of esophagus
stomach cancer 10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
bile duct carcinoma 4897
trachea squamous cell carcinoma 12003 Tracheal Epidermoid carcinoma, squamous cell carcinoma of trachea
pharynx squamous cell carcinoma 0050921
endometrial cancer 1380 primary malignant neoplasm of endometrium, neoplasm of endometrium (disorder), endometrial neoplasm, malignant endometrial neoplasm, endometrial Ca, malignant neoplasm of endometrium, tumor of Endometrium
lung cancer 1324
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
acute lymphocytic leukemia 9952
cancer 162 malignant tumor, malignant neoplasm, primary cancer
pancreatic ductal adenocarcinoma 3498 ductal adenocarcinoma of the pancreas
esophagus adenocarcinoma 4914 Oesophageal adenocarcinoma, adenocarcinoma of esophagus
astrocytoma 3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
Interactors (11)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P11802 CDK4  3 0.948 15
 UniProt:Q00534 CDK6  3 0.934 15
 UniProt:P12004 PCNA  5 0.61 8
 UniProt:P02730 SLC4A1  8 0.602 5
 UniProt:Q6UXH1 CREL2      0.508 2
 UniProt:Q00839 HNRNPU  1 0.508 2
 UniProt:Q8NHU6 TDRD7      0.508 2
 UniProt:O75398 DEAF1      0.508 2
 UniProt:Q14566 MCM6  1 0.499 4
 UniProt:P24385 CCND1  4 0.491 2
 UniProt:P62826 RAN  2 0.463 2
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