Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pS, p-T410-PRKCZ [cytosol]
Stable Identifier
R-HSA-9632824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, zeta type, phosphorylated (Thr-410) , nPKC-zeta
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
Estrogen-stimulated signaling through PRKCZ (Homo sapiens)
ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
PRKCZ autophosphorylates downstream of estrogen stimulation (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
PRKCZ recruits RAS in response to estrogen stimulation (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
PRKCZ stimulates RAS nucleotide exchange in response to estrogen (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GDP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] (Homo sapiens)
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
pS, p-T410-PRKCZ [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05513 PRKCZ
Gene Names
PRKCZ, PKC2
Chain
chain:1-592
Reference Genes
BioGPS Gene:5590 PRKCZ
COSMIC (genes):PRKCZ PRKCZ
CTD Gene:5590 PRKCZ
dbSNP Gene:5590 PRKCZ
ENSEMBL:ENSG00000067606 PRKCZ
ENSEMBL_homo_sapiens_GENE:ENSG00000067606.17 PRKCZ
HGNC:9412 PRKCZ
KEGG Gene (Homo sapiens):5590 PRKCZ
Monarch:5590 PRKCZ
NCBI Gene:5590 PRKCZ
OMIM:176982 PRKCZ
UCSC:Q05513 PRKCZ
Reference Transcript
RefSeq:NM_002744.4 PRKCZ
RefSeq:NM_001033582.1 PRKCZ
RefSeq:XM_017001799.1 PRKCZ
RefSeq:NM_001242874.1 PRKCZ
RefSeq:NM_001033581.1 PRKCZ
Other Identifiers
11716375_s_at
11739001_s_at
11747845_x_at
202178_PM_at
202178_at
2316269
2316275
2316279
2316280
2316282
2316285
2316297
2316298
2316299
2316300
2316303
2316304
2316321
2316322
2316323
2316324
2316325
2316326
2316327
2316328
2316329
362_at
4054482
4054508
4054510
4054511
4054530
4054536
5590
7897044
A_23_P51187
GE60356
GO:0000166
GO:0000226
GO:0001725
GO:0001954
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005635
GO:0005737
GO:0005768
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005923
GO:0005938
GO:0006351
GO:0006355
GO:0006468
GO:0006954
GO:0007010
GO:0007018
GO:0007155
GO:0007163
GO:0007165
GO:0007166
GO:0007616
GO:0008284
GO:0012501
GO:0014069
GO:0015459
GO:0016020
GO:0016301
GO:0016310
GO:0016324
GO:0016363
GO:0016477
GO:0016740
GO:0018105
GO:0019901
GO:0023052
GO:0030010
GO:0030054
GO:0030154
GO:0031252
GO:0031333
GO:0031410
GO:0031982
GO:0032733
GO:0032736
GO:0032753
GO:0032754
GO:0032869
GO:0035556
GO:0035748
GO:0036211
GO:0043066
GO:0043203
GO:0043226
GO:0043274
GO:0043560
GO:0044877
GO:0045179
GO:0045197
GO:0045630
GO:0046627
GO:0046628
GO:0046872
GO:0047496
GO:0048471
GO:0048856
GO:0048870
GO:0050732
GO:0050806
GO:0050877
GO:0051092
GO:0051222
GO:0051899
GO:0060081
GO:0060291
GO:0065003
GO:0070062
GO:0070160
GO:0070161
GO:0070374
GO:0070528
GO:0071889
GO:0072659
GO:0080090
GO:0098685
GO:0098696
GO:0098772
GO:0098978
GO:0106310
GO:0120157
GO:0140096
GO:1990138
GO:2000463
GO:2000553
HMNXSV003020065
HMNXSV003056064
ILMN_1662155
ILMN_1697267
ILMN_1775050
ILMN_2386982
PH_hs_0028347
Z15108_at
g10864649_3p_at
Participates
as a component of
PDPK1:PIP3:pS, p-T410 PRKCZ [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-T410,T563-PRKCZ [cytosol]
PRKCZ [cytosol]
PRKCZ [cell junction]
p-T410-PRKCZ [cytosol]
Inferred To
phospho-PRKCZ [cytosol]
(Gallus gallus)
phospho-pS, p-T410-PRKCZ [cytosol]
(Bos taurus)
phospho-pS, p-T410-PRKCZ [cytosol]
(Caenorhabditis elegans)
phospho-pS, p-T410-PRKCZ [cytosol]
(Canis familiaris)
phospho-pS, p-T410-PRKCZ [cytosol]
(Dictyostelium discoideum)
phospho-pS, p-T410-PRKCZ [cytosol]
(Drosophila melanogaster)
phospho-pS, p-T410-PRKCZ [cytosol]
(Mus musculus)
phospho-pS, p-T410-PRKCZ [cytosol]
(Rattus norvegicus)
phospho-pS, p-T410-PRKCZ [cytosol]
(Saccharomyces cerevisiae)
phospho-pS, p-T410-PRKCZ [cytosol]
(Schizosaccharomyces pombe)
phospho-pS, p-T410-PRKCZ [cytosol]
(Sus scrofa)
Homologues of pS, p-T410-PRKCZ [cytosol]
(Dictyostelium discoideum)
Homologues of pS, p-T410-PRKCZ [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-threonine at 410
Coordinate
410
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001229803.1
,
XP_016857288.1
,
NP_002735.3
,
NP_001028753.1
,
NP_001028754.1
Guide to Pharmacology - Targets
1491
OpenTargets
ENSG00000067606
ZINC - Substances
KPCZ_HUMAN
ZINC - Biogenic
KPCZ_HUMAN
ZINC target
Q05513
PRO
Q05513
ZINC - Investigational
KPCZ_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000067606-PRKCZ
GeneCards
Q05513
Ensembl
ENST00000378567
,
ENSP00000426412
,
ENST00000461106
,
ENSG00000067606
,
ENSP00000367830
,
ENSP00000383712
,
ENST00000400921
Pharos - Targets
Q05513
ZINC - Predictions - Purchasable
KPCZ_HUMAN
HMDB Protein
HMDBP01374
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYG5 PARD6B
2
PARD6B [plasma membrane]
(R-HSA-418193)
PARD6B [cytosol]
(R-HSA-419973)
0.949
18
UniProt:Q9NPB6 PARD6A
4
PARD6A [plasma membrane]
(R-HSA-418187)
PARD6A [cytosol]
(R-HSA-420001)
PARD6A [cell junction]
(R-HSA-2134480)
p-S345-PARD6A [plasma membrane]
(R-HSA-2134533)
0.906
10
UniProt:Q9BYG4 PARD6G
2
PARD6G [plasma membrane]
(R-HSA-418192)
PARD6G [cytosol]
(R-HSA-419967)
0.886
9
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.886
10
UniProt:Q15334 L2GL1
0.837
9
UniProt:Q6P1M3 L2GL2
0.725
8
UniProt:O75323 GBAS
1
NIPSNAP2 [cytosol]
(R-HSA-9714668)
0.725
5
UniProt:Q13501 SQSTM1
7
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
SQSTM1 [cytosol]
(R-HSA-193937)
0.725
6
UniProt:Q07021 C1QBP
3
C1QBP [cytosol]
(R-HSA-9645690)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
0.669
4
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.612
6
UniProt:P49757-1 NUMB
0.602
4
UniProt:Q04759 PRKCQ
9
PRKCQ [photoreceptor disc membrane]
(R-HSA-2648997)
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-2685606)
PRKCQ(1-354) [cytosol]
(R-HSA-212526)
PRKCQ(355-706) [cytosol]
(R-HSA-212514)
PRKCQ [cytosol]
(R-HSA-58216)
PRKQC closed conformation [cytosol]
(R-HSA-202185)
PRKCQ [plasma membrane]
(R-HSA-202346)
p-Y90-PRKCQ [plasma membrane]
(R-HSA-202395)
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-202152)
0.581
3
UniProt:P14598 NCF1
4
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.544
2
UniProt:Q9Y624 F11R
2
F11R [cell junction]
(R-HSA-2134498)
F11R [plasma membrane]
(R-HSA-197845)
0.536
2
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.527
2
UniProt:Q9Y5S2 CDC42BPB
1
CDC42BPB [cytosol]
(R-HSA-419873)
0.527
2
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.527
2
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.527
2
UniProt:Q8IX03 WWC1
1
WWC1 [cytosol]
(R-HSA-2038400)
0.527
4
UniProt:O43852 CALU
3
CALU [endoplasmic reticulum lumen]
(R-HSA-350695)
p-CALU [endoplasmic reticulum lumen]
(R-HSA-8956931)
CALU [extracellular region]
(R-HSA-350739)
0.527
2
UniProt:O00410 IPO5
1
IPO5 [nucleoplasm]
(R-HSA-192675)
0.527
2
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.527
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
UniProt:O95999 BCL10
3
K48polyUb-BCL10 [cytosol]
(R-HSA-8939329)
BCL10 [cytosol]
(R-HSA-202447)
p-BCL10 [cytosol]
(R-HSA-202488)
0.518
3
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.463
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text