Reactome | p-S10 CDKN1B translocates to the cytosol

p-S10 CDKN1B translocates to the cytosol

Stable Identifier

R-HSA-9632873

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytoplasm

ReviewStatus

5/5

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p-S10 CDKN1B translocates to the cytosol

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Estrogen stimulation causes a partial redistribution of CDKN1B into the cytosol in a manner that depends on Ras and PI3K signaling and the atypical PKC zeta (Rodier et al, 2002; Castoria et al, 2004). Nuclear localization of CDKN1B inhibits cell cycle progression (Reynisdottir et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
15314172	Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells Auricchio, F, Di Domenico, M, Barone, MV, Bilancio, A, de Falco, A, Lombardi, M, Castoria, G, Migliaccio, A, Varricchio, L	Mol. Cell. Biol.	2004
11726503	p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis Meloche, S, Coulombe, P, Rodier, G, Montagnoli, A, Di Marcotullio, L, Pagano, M, Draetta, GF	EMBO J.	2001
9042862	The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2 Reynisdóttir, I, Massagué, J	Genes Dev.	1997