ESR1- and PRCKZ-dependent MAPK1 translocation to the nucleus

Stable Identifier
R-HSA-9632910
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAPK1 (also known as ERK2) translocates to the nucleus in response to estrogen stimulation several cell lines in a manner that also depends on SRC, PI3K and PRCKZ (Castoria et al, 2004). RAS signaling and ERK2 nuclear translocation promotes estrogen-dependent stimulation of cell cycle progression (Castoria et al, 1999; Castoria et al, 2001; Migliaccio et al, 1996; Castoria et al, 2004; Rodier et al, 2002; Foster et al, 2003;reviewed in Castoria et al, 2010).

Literature References
PubMed ID Title Journal Year
12904306 Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway

Foster, JS, Fernando, RI, Ishida, N, Nakayama, KI, Wimalasena, J

J. Biol. Chem. 2003
15314172 Role of atypical protein kinase C in estradiol-triggered G1/S progression of MCF-7 cells

Castoria, G, Migliaccio, A, Di Domenico, M, Lombardi, M, de Falco, A, Varricchio, L, Bilancio, A, Barone, MV, Auricchio, F

Mol. Cell. Biol. 2004
8635462 Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells

Migliaccio, A, Di Domenico, M, Castoria, G, de Falco, A, Bontempo, P, Nola, E, Auricchio, F

EMBO J. 1996
19879889 Cell proliferation regulated by estradiol receptor: Therapeutic implications

Castoria, G, Migliaccio, A, Giovannelli, P, Auricchio, F

Steroids 2010
10228164 Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

Castoria, G, Barone, MV, Di Domenico, M, Bilancio, A, Ametrano, D, Migliaccio, A, Auricchio, F

EMBO J. 1999
11726503 p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

Rodier, G, Montagnoli, A, Di Marcotullio, L, Coulombe, P, Draetta, GF, Pagano, M, Meloche, S

EMBO J. 2001
11689445 PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

Castoria, G, Migliaccio, A, Bilancio, A, Di Domenico, M, de Falco, A, Lombardi, M, Fiorentino, R, Varricchio, L, Barone, MV, Auricchio, F

EMBO J. 2001
Participants
Participant Of
This event is regulated
Orthologous Events
Authored
Reviewed
Created