p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1

Stable Identifier
R-HSA-9633008
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After binding uncharged tRNA and autophosphorylating, EIF2AK4 (GCN2) phosphorylates EIF2S1 (eIF2 alpha subunit) on serine-52 (serine-51 in the rabbit homolog, inferred from mouse homologs and yeast homologs), which inhibits the guanine nucleotide exchange factor eIF2B, impairs exchange of GDP for GTP, and reduces recycling of EIF2 for initiation of translation. This causes downregulation of translation of most mRNAs, however translation of certain mRNAs possessing upstream ORFs, such as ATF4, is upregulated (inferred from mouse homologs and yeast homologs).

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Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol]
Physical Entity
Activity
Inferred From
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