SHC1 binds phosphorylated ERBB2 homodimer

Stable Identifier
R-HSA-9634391
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SHC1 binds to autophosphorylated ERBB2 homodimers (Pickl and Ries 2009). As PTPN12 dephosphorylates tyrosine Y1248 of ERBB2, inhibiting SHC1 binding to ERBB2 (Sun et al. 2011), and as Y1248 is autophosphorylated in ERBB2 homodimers (Pickl and Ries 2009, Maadi et al. 2018), it is assumed that PTPN12 negatively regulates SHC1 binding to ERBB2 homodimers.

Literature References
Participants
Participates
This event is regulated
Negatively by
Regulator
Summation

Binding of SHC1 to activated ERBB2 and the consequent RAS signaling activation is inhibited by the action of the PTPN12 protein tyrosine phosphatase. PTNP12 dephosphorylates tyrosine residue Y1248 of activated ERBB2 which serves as one of the docking sites for SHC1 in the ERBB2 C-terminus (Sun et al. 2011).

Normal reaction
Functional status

Increased translational product level of p-ERBB2 homodimer [plasma membrane]

Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
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Reviewed
Created
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