CSF3R gene expression is enhanced by SPI1 (PU.1), CEBPA, and DEK

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R-HSA-9634429
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Reaction [omitted]
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Homo sapiens
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SPI1 (PU.1) and CEBPA bind the promoter of the CSF3R (G-CSFR) gene and synergistically activate transcription of CSF3R (Smith et al. 1996, Tavor et al. 2003). Absence of CEBPA binding reduces transcription by about 60% and absence of SPI1 binding reduces transcription by about 75% (Smith et al. 1996). DEK interacts with CEBPA at the CSF3R promoter and enhances transcription (Koleva et al. 2012). DEK is required for CSF3 (G-CSF) mediated granulocyte differentiation (Koleva et al. 2012).

Literature References
PubMed ID Title Journal Year
8695841 PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells

Smith, LT, Hohaus, S, Gonzalez, DA, Dziennis, SE, Tenen, DG

Blood 1996
14517214 Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation

Tavor, S, Park, DJ, Gery, S, Vuong, PT, Gombart, AF, Koeffler, HP

J. Biol. Chem. 2003
22474248 C/EBPα and DEK coordinately regulate myeloid differentiation

Koleva, RI, Ficarro, SB, Radomska, HS, Carrasco-Alfonso, MJ, Alberta, JA, Webber, JT, Luckey, CJ, Marcucci, G, Tenen, DG, Marto, JA

Blood 2012
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