KLF5 gene expression is enhanced by CEBPA

Stable Identifier
R-HSA-9634442
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
CEBPA binds two sites in the promoter of the KLF5 gene and activates transcription (Federzoni et al. 2014, and inferred from mouse homologs). An indirect mechanism of activation may exist, as mutation of the CEBPA binding sites does not impair activation of KLF5 by CEBPA (Federzoni et al. 2014). In mouse 32D cells, KLF5 is required for granulocyte differentiation and in some cases of human acute myelogenous leukemia (AML), KLF5 is silenced by hypermethylation (Diakiw et al. 2012).
Literature References
PubMed ID Title Journal Year
24584857 CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation

Tschan, MP, Humbert, M, Fey, MF, Federzoni, EA, Behre, G, Torbett, BE

Sci Rep 2014
21993314 The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia

D'Andrea, RJ, Lewis, ID, Diakiw, SM, Brown, AL, To, LB, Kok, CH

Leuk. Res. 2012
Participants
Participates
This event is regulated
Inferred From
Authored
Reviewed
Created
Cite Us!