CEBPA binds two sites in the promoter of the KLF5 gene and activates transcription (Federzoni et al. 2014, and inferred from mouse homologs). An indirect mechanism of activation may exist, as mutation of the CEBPA binding sites does not impair activation of KLF5 by CEBPA (Federzoni et al. 2014). In mouse 32D cells, KLF5 is required for granulocyte differentiation and in some cases of human acute myelogenous leukemia (AML), KLF5 is silenced by hypermethylation (Diakiw et al. 2012).