KLF5 gene expression is enhanced by CEBPA

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R-HSA-9634442
Type
Reaction [omitted]
Species
Homo sapiens
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CEBPA binds two sites in the promoter of the KLF5 gene and activates transcription (Federzoni et al. 2014, and inferred from mouse homologs). An indirect mechanism of activation may exist, as mutation of the CEBPA binding sites does not impair activation of KLF5 by CEBPA (Federzoni et al. 2014). In mouse 32D cells, KLF5 is required for granulocyte differentiation and in some cases of human acute myelogenous leukemia (AML), KLF5 is silenced by hypermethylation (Diakiw et al. 2012).

Literature References
PubMed ID Title Journal Year
21993314 The granulocyte-associated transcription factor Kr├╝ppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia

Diakiw, SM, Kok, CH, To, LB, Lewis, ID, Brown, AL, D'Andrea, RJ

Leuk. Res. 2012
24584857 CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation

Federzoni, EA, Humbert, M, Torbett, BE, Behre, G, Fey, MF, Tschan, MP

Sci Rep 2014
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