E2F1, phospho-STAT3, and CEBPB bind the promoter of the MYC gene and enhance transcription while CEBPA interacts with E2F1 at the MYC promoter and inhibits transcription (D'Alo' et al. 2003, Tavor et al. 2003, Hirai et al. 2006, and inferred from mouse homologs). CEBPB reduces the residency of CEBPA at the MYC promoter (inferred from mouse homologs). CEBPB appears to inhibit expression of MYC less than CEBPA does (Hirai et al. 2006), thus the ratio of CEBPB and CEBPA is believed to determine the proliferation (promoted by CEBPB) and differentiation (promoted by CEBPA) of neutrophil progenitors.
Vuong, PT, Gery, S, Park, DJ, Gombart, AF, Koeffler, HP, Tavor, S
Hirai, H, Dayaram, T, Hetherington, CJ, Imanishi, J, Zhang, P, Tenen, DG, Mizuno, S, Akashi, K
Evans, EK, Nerlov, C, Radomska, HS, Nelson, EA, Johansen, LM, Zhang, P, D'Alo', F, Tenen, DG
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