Regulation of glycolysis by fructose 2,6-bisphosphate metabolism

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R-HSA-9634600
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Pathway
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Homo sapiens
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The committed step of glycolysis is the phosphorylation of D-fructose 6-phosphate (Fru(6)P) to form D-fructose 1,6-bisphosphate, catalyzed by phosphofructokinase 1 (PFK) tetramer. PFK can be allosterically activated by D-fructose 2,6-bisphosphate whose levels are increased in response to insulin signaling and decreased in response to glucagon signaling, through the reactions annotated here (Pilkis et al. 1995).

Literature References
PubMed ID Title Journal Year
7574501 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme.

Pilkis, SJ, Claus, TH, Kurland, IJ, Lange, AJ

Annu Rev Biochem 1995
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