Reactome | ARNTL [nucleoplasm]

ARNTL [nucleoplasm]

Stable Identifier

R-HSA-9634872

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Aryl hydrocarbon receptor nuclear translocator-like protein 1, BMAL1, Brain and muscle ARNT-like 1, BHLHE5, MOP3, PASD3

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Locations in the PathwayBrowser for interactor UniProt:Q99743 NPAS2

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 binds ARNTL (BMAL1) (Homo sapiens)
        
        ARNTL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00327 ARNTL

Gene Names

ARNTL, BHLHE5, BMAL1, MOP3, PASD3

Chain

chain:1-626

Reference Genes

BioGPS Gene:406 BMAL1

COSMIC (genes):ARNTL ARNTL

CTD Gene:406 BMAL1

dbSNP Gene:406 BMAL1

ENSEMBL:ENSG00000133794 ARNTL

HGNC:701 BMAL1

KEGG:hsa:406 BMAL1

Monarch:406 BMAL1

NCBI Gene:406 BMAL1

OMIM:602550 BMAL1

UCSC:O00327 BMAL1

Reference Transcript

Participates

as an input of

NPAS4 binds ARNTL (BMAL1) (Homo sapiens)

as a component of

NPAS4:ARNTL [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S-ARNTL [nucleoplasm]

p-S90-BMAL1 [cytosol]

p-S90-BMAL1 [nucleoplasm]

ARNTL [cytosol]

p-S90,Ac-K538-BMAL1 [nucleoplasm]

Inferred To

cyc [nucleoplasm] (Drosophila melanogaster)

Bmal1 [nucleoplasm] (Mus musculus)

Met [nucleoplasm] (Drosophila melanogaster)

Homologues of ARNTL [nucleoplasm] (Drosophila melanogaster)

gce [nucleoplasm] (Drosophila melanogaster)

ARNTL [nucleoplasm] (Bos taurus)

ARNTL [nucleoplasm] (Sus scrofa)

BMAL1 [nucleoplasm] (Canis familiaris)

bmal1 [nucleoplasm] (Xenopus tropicalis)

bmal1a [nucleoplasm] (Danio rerio)

Arntl [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001025444.1, XP_011518414.1, NP_001025443.1, XP_016873235.1, XP_016873236.1, XP_016873237.1, NP_001284648.1, NP_001284653.1, NP_001284651.1, NP_001169.3, XP_016873232.1, XP_016873231.1, XP_011518415.1

OpenTargets

ENSG00000133794

ENSEMBL

ENST00000529388, ENSP00000385581, ENST00000389707, ENSP00000433571, ENSP00000385897, ENSG00000133794, ENST00000403290, ENSP00000385915, ENSP00000384517, ENSP00000374357, ENST00000403482, ENST00000403510, ENST00000401424

HPA

ENSG00000133794-BMAL1

GeneCards

BMAL1

PRO

O00327

Pharos - Targets

O00327

GlyGen

O00327

PDB

4H10

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15516 CLOCK	7	p-S-CLOCK [nucleoplasm] (R-HSA-421310) p-T451,T461-CLOCK [cytosol] (R-HSA-9912397) p-T451,T461-CLOCK [nucleoplasm] (R-HSA-9920699) CLOCK [cytosol] (R-HSA-400392) CLOCK [nucleoplasm] (R-HSA-879828) p-T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (R-HSA-9920715) p-S,T451,T461,S440,S441,S446-CLOCK [nucleoplasm] (R-HSA-9922270)	0.796	7
UniProt:Q99743 NPAS2	2	NPAS2 [cytosol] (R-HSA-400314) p-NPAS2 [nucleoplasm] (R-HSA-421309)	0.632	4
UniProt:D0VY79 D0VY79			0.556	3
UniProt:Q9Y463 DYR1B			0.527	2

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