MyrG-CDK5R1 binds CDK5

Stable Identifier
R-HSA-9634943
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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CDK5R1 is a neuron-specific regulatory subunit of CDK5 that activates CDK5 kinase activity in a cyclin-type manner and CDK5R1 and CDK5 co-precipitate from rat PC12 cells and from bovine brain (Tsai et al, 1994; Lew et al, 1994; Harada et al, 2001). CDK5 activity is required for neurite outgrowth and disruption of CDK5 or CDK5R1 leads to defects in neuronal migration in mice (Nikolic et al, 1996; Xiong et al, 1997; Paglini et al, 1998).

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