Reactome | CTSG [cytosol]

CTSG [cytosol]

Stable Identifier

R-HSA-9635429

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cathepsin G, CATG_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q15323 KRT31

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 processing (Homo sapiens)
        
        CTSG cleaves CASP1(1-404) (Homo sapiens)
        
        CTSG [cytosol] (Homo sapiens)

General

After secretion Cathepsin G is extracellular and associated with the plasma membrane.

Literature References

PubMed ID	Title	Journal	Year
2681419	Elastase and cathepsin G of human monocytes. Quantification of cellular content, release in response to stimuli, and heterogeneity in elastase-mediated proteolytic activity Campbell, EJ, Silverman, EK, Campbell, MA	J Immunol	1989

External Reference Information

External Reference

UniProt:P08311 CTSG

Gene Names

CTSG

Chain

signal peptide:1-18, propeptide:19-20, chain:21-255

Reference Genes

BioGPS Gene:1511 CTSG

COSMIC (genes):CTSG CTSG

CTD Gene:1511 CTSG

dbSNP Gene:1511 CTSG

ENSEMBL:ENSG00000100448 CTSG

HGNC:2532 CTSG

KEGG Gene (Homo sapiens):1511 CTSG

Monarch:1511 CTSG

NCBI Gene:1511 CTSG

OMIM:116830 CTSG

UCSC:P08311 CTSG

Reference Transcript

RefSeq:NM_001911.2 CTSG

Other Identifiers

0003780086

11723339_at

1511

16791427

205653_at

3558348

3558349

3558350

3558352

3558353

3558354

3558357

3558358

37105_at

679_at

7978351

A_23_P140384

GE57841

GO:0002003

GO:0002376

GO:0003013

GO:0003674

GO:0004252

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005764

GO:0005773

GO:0005886

GO:0006464

GO:0006468

GO:0006508

GO:0006810

GO:0006950

GO:0006955

GO:0008150

GO:0008201

GO:0008233

GO:0008236

GO:0009986

GO:0010494

GO:0016192

GO:0016787

GO:0019730

GO:0019731

GO:0022617

GO:0030141

GO:0030198

GO:0031012

GO:0031410

GO:0032496

GO:0034641

GO:0035578

GO:0042742

GO:0043167

GO:0043226

GO:0043312

GO:0044267

GO:0044403

GO:0050778

GO:0050829

GO:0050830

GO:0050832

GO:0051604

GO:0062023

GO:0070062

GO:0070946

GO:0071222

ILMN_1680424

J04990_at

TC14000980.hg

g4503148_3p_at

Participant Of

hasComponent

Rv3364c:CTSG [cytosol]

input

Rv3364c binds cathepsin G

Other forms of this molecule

CTSG [azurophil granule lumen]

CTSG [extracellular region]

CTSG [plasma membrane]

Inferred To

CTSG [cytosol] (Bos taurus)

Ctsg [cytosol] (Mus musculus)

Ctsg [cytosol] (Rattus norvegicus)

Homologues of CTSG [cytosol] (Danio rerio)

gzm3.3 [cytosol] (Danio rerio)

gzm3.2 [cytosol] (Danio rerio)

gzm3 [cytosol] (Danio rerio)

gzm3.4 [cytosol] (Danio rerio)

ctsg [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001902.1

ZINC - World Drugs

CATG_HUMAN

OpenTargets

ENSG00000100448

ZINC - FDA approved

CATG_HUMAN

ZINC - Substances

CATG_HUMAN

ZINC - Biogenic

CATG_HUMAN

ZINC target

P08311

PRO

P08311

PDB

1CGH, 1KYN, 6VTM, 1AU8, 1T32

ZINC - Investigational

CATG_HUMAN

IntEnz

3.4.21.20

GeneCards

P08311

HPA

ENSG00000100448-CTSG

Ensembl

ENSG00000100448, ENST00000216336, ENSP00000216336

ZINC - Predictions - Purchasable

CATG_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3