Infection with Mycobacterium tuberculosis

Stable Identifier
R-HSA-9635486
Type
Pathway
Species
Homo sapiens
Related Species
Mycobacterium tuberculosis
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Infection with Mycobacterium tuberculosis (Mtb) is soon countered by the host's immune system, the organism is however almost never eradicated; ten per cent of infections will develop into "open tuberculosis", while the other ninety per cent become "latent", a state that can persist for decades until loss of immune control. Approximately 25% of the world's population is estimated to harbour latent tuberculosis. Latent infection involves the bacterium being internalized by phagocytes where it stops and counters the innate immune answer (Russell 2011, Russell et al. 2010). When a status-quo is reached, Mtb enters a non-replicating persistent state (Barry et al. 2009, Boshoff & Barry 2005). Weakening of the immune defense sooner or later enables the waking up and multiplication of the bacterium inside the phagocyte, necrosis of the cell, and escape, analogous to the burst of lytic viruses (Repasy 2013).

Literature References
PubMed ID Title Journal Year
23436998 Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo

Repasy, T, Lee, J, Marino, S, Martinez, N, Kirschner, DE, Hendricks, G, Baker, S, Wilson, AA, Kotton, DN, Kornfeld, H

PLoS Pathog. 2013
21349098 Mycobacterium tuberculosis and the intimate discourse of a chronic infection

Russell, DG

Immunol Rev 2011
19855401 The spectrum of latent tuberculosis: rethinking the biology and intervention strategies

Barry CE, 3rd, Boshoff, HI, Dartois, V, Dick, T, Ehrt, S, Flynn, J, Schnappinger, D, Wilkinson, RJ, Young, D

Nat Rev Microbiol 2009
20466922 Tuberculosis: what we don't know can, and does, hurt us

Russell, DG, Barry CE, 3rd, Flynn, JL

Science 2010
15608701 Tuberculosis - metabolism and respiration in the absence of growth

Boshoff, HI, Barry CE, 3rd

Nat Rev Microbiol 2005
Participants
Participant Of
Event Information
Go Biological Process
Disease
Name Identifier Synonyms
tuberculosis 399 tuberculous abscess, Tuberculoma (finding), tuberculoma
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Reviewed
Created